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ML281

ML281

  • CAT Number: I001552
  • CAS Number: 1404437-62-2
  • Molecular Formula: C22H19N3O2S
  • Molecular Weight: 389.5
  • Purity: ≥95%
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ML281(CAT: I001552) is a potent and selective inhibitor of the serine/threonine kinase 33 (STK33). STK33 is involved in various cellular processes, including cell proliferation, cell cycle regulation, and tumorigenesis. By inhibiting the activity of STK33, ML281 has the potential to modulate these cellular processes and may have therapeutic implications in diseases where STK33 dysregulation is implicated, such as cancer. Its selectivity towards STK33 makes it a valuable tool compound for studying the function of this kinase and its potential as a therapeutic target.

Catalog Number I001552
CAS Number 1404437-62-2
Molecular Formula

C22H19N3O2S

Purity 95%
Target target: STK33
Solubility 5.6 μM in DMSO
Storage -20°C
InChIKey HWOYIOLMBQSTQS-UHFFFAOYSA-N
Reference

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<br>[1]. Spoonamore J et al. Screen for Inhibitors of STK33 Kinase Activity. National Center for Biotechnology Information (US); 2010-2011 Dec 16.

<br>[2]. We?wer M et al. A Potent and Selective Quinoxalinone-Based STK33 Inhibitor Does Not Show Synthetic Lethality in KRAS-Dependent Cells. ACS Med Chem Lett, 2012 Dec 13, 3(12):1034-1038.

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