MK-8931- CAS 1286770-55-5

CAS No.: 1286770-55-5

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MK-8931,1286770-55-5
Product Details
For research use only. Not Intended for Therapeutic Use!
Cat No:I001120
Synonyms:

(R)-5-fluoro-N-(4-fluoro-3-(3-imino-2,5-dimethyl-1,1-dioxido-1,2,4-thiadiazinan-5-yl)phenyl)picolinamide 2,2,2-trifluoroacetate

Molecular Formula:

C₁₇H₁₇F₂N₅O₃S

Molecular Weight:409.41
Description:MK-8931 is a BACE1 inhibitor. MK-8931 binds significantly to β-secretase.target: BACE1.
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MK-8931 is a BACE1 inhibitor. MK-8931 binds significantly to β-secretase.
target: BACE1.
In vitro:MK-8931 can effectively reduce Aβ40 in cells with a Ki of 7.8 nM and an IC50 of 13 nM. [1] Docking revealed that, with respect to their free binding energy, acylguanidine 7a has the lowest binding energy followed by MK-8931 and pioglitazone and binds significantly to β-secretase. [2]

Chem Calculators

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