Methylene Blue

• CAT Number: A000087
• CAS Number: 61-73-4
• Molecular Formula: C16H18ClN3S
• Molecular Weight: 319.85
• Purity: ≥95%
• Storage: Store at -20°C
• InChI: 1S/C16H18N3S.ClH/c1-18(2)11-5-7-13-15(9-11)20-16-10-12(19(3)4)6-8-14(16)17-13;/h5-10H,1-4H3;1H/q+1;/p-1
• InChIKey: CXKWCBBOMKCUKX-UHFFFAOYSA-M
• SMILES: CN(C1=CC2=[S+]C3=C(C=CC(N(C)C)=C3)N=C2C=C1)C.[Cl-]

Methylene Blue (Cat No.:A000087) is used as a dye in neuroanatomy and bacteriology; in biochemical studies, methylene blue acts as an indicator of redox. As an antidote, methylene orchid is used to treat methemoglobinemia caused by nitrite poisoning, etc. Also, methylene orchid is used to treat cyanide poisoning and isocyclophosphamide-induced encephalopathy.

Reference

1: Nemezio MA, de Souza Farias SS, Borsatto MC, Aires CP, Corona SAM. Effect of
methylene blue-induced photodynamic therapy on a Streptococcus mutans biofilm
model. Photodiagnosis Photodyn Ther. 2017 Oct 31. pii: S1572-1000(17)30291-0.
doi: 10.1016/j.pdpdt.2017.10.025. [Epub ahead of print] PubMed PMID: 29101088.

2: Manji F, Wierstra B, Posadas J. Severe Undifferentiated Vasoplegic Shock
Refractory to Vasoactive Agents Treated with Methylene Blue. Case Rep Crit Care.
2017;2017:8747326. doi: 10.1155/2017/8747326. Epub 2017 Oct 2. PubMed PMID:
29098094; PubMed Central PMCID: PMC5642875.

3: Müller Ramalho K, Ribeiro Cunha S, Mayer-Santos E, de Paula Eduardo C, de
Freitas PM, Cecilia Correa Aranha A, Moura-Netto C. In vitro evaluation of
methylene blue removal from root canal after photodynamic therapy. Photodiagnosis
Photodyn Ther. 2017 Oct 30. pii: S1572-1000(17)30378-2. doi:
10.1016/j.pdpdt.2017.10.024. [Epub ahead of print] PubMed PMID: 29097290.

4: Tang Z, He J, Chen J, Niu Y, Zhao Y, Zhang Y, Yu C. A sensitive sandwich-type
immunosensor for the detection of galectin-3 based on N-GNRs-Fe-MOFs@AuNPs
nanocomposites and a novel AuPt-methylene blue nanorod. Biosens Bioelectron. 2017
Oct 16;101:253-259. doi: 10.1016/j.bios.2017.10.026. [Epub ahead of print] PubMed
PMID: 29096363.

5: Tong L, Wang Z, Xia C, Yang Y, Yuan S, Sun D, Xin X. Self-Assembly of
Peptide-Polyoxometalate Hybrid Sub-micrometer Spheres for Photocatalytic
Degradation of Methylene Blue. J Phys Chem B. 2017 Nov 2. doi:
10.1021/acs.jpcb.7b07100. [Epub ahead of print] PubMed PMID: 29095615.

6: Booth AT, Melmer PD, Tribble B, Mehaffey JH, Tribble C. Methylene Blue for
Vasoplegic Syndrome. Heart Surg Forum. 2017 Oct 31;20(5):E234-E238. doi:
10.1532/hsf.1806. PubMed PMID: 29087290.

7: Park JA, Yang B, Lee J, Kim IG, Kim JH, Choi JW, Park HD, Nah IW, Lee SH.
Ultrasonic spray pyrolysis synthesis of reduced graphene oxide/anatase TiO(2)
composite and its application in the photocatalytic degradation of methylene blue
in water. Chemosphere. 2017 Oct 17;191:738-746. doi:
10.1016/j.chemosphere.2017.10.094. [Epub ahead of print] PubMed PMID: 29078195.

8: Wang J, Meng X, Yuan Z, Tian Y, Bai Y, Jin Z. Acrylated Composite Hydrogel
Preparation and Adsorption Kinetics of Methylene Blue. Molecules. 2017 Oct
26;22(11). pii: E1824. doi: 10.3390/molecules22111824. PubMed PMID: 29072617.

9: Kirby GC, Macano CAW, Nyasavajjala SM, Sahloul M, Nijjar R, Daskalakis M,
Richardson M, Singhal R. The Birmingham experience of high-pressure methylene
blue dye test during primary and revisional bariatric surgery: A retrospective
cohort study. Ann Med Surg (Lond). 2017 Sep 28;23:32-34. doi:
10.1016/j.amsu.2017.09.015. eCollection 2017 Nov. PubMed PMID: 29071067; PubMed
Central PMCID: PMC5651492.

10: Wang G, Liu X, Wang S, Ge N, Guo J, Sun S. Saline with methylene
blue-assisted endoscopic ultrasound-guided gastrojejunostomy using a
double-flared fully covered metal stent. Endoscopy. 2017 Oct 25. doi:
10.1055/s-0043-119981. [Epub ahead of print] PubMed PMID: 29069704.