Methimazole

  • CAT Number: A000359
  • CAS Number: 60-56-0
  • Molecular Formula: C4H6N2S
  • Molecular Weight: 114.17
  • Purity: ≥95%
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Methimazole (also known as Thiamazole, NSC-38608, and Favistan) is a thioureylene antithyroid agent that inhibits the formation of thyroid hormones by interfering with the incorporation of iodine into tyrosyl residues of thyroglobulin. Methimazole is used to treat hyperthyroidism and psoriasis.

Catalog Number A000359
CAS Number 60-56-0
Molecular Formula

C4H6N2S

Purity 95%
Target Thyroid Peroxidase Inhibitor
Storage -20°C
InChI 1S/C4H6N2S/c1-6-3-2-5-4(6)7/h2-3H,1H3,(H,5,7)
InChIKey PMRYVIKBURPHAH-UHFFFAOYSA-N
SMILES CN1C=CNC1=S
Reference

1: Birmingham A, Mancuso C, Williams C. Use of granulocyte colony-stimulating
factor in the treatment of methimazole-induced agranulocytosis: a case report.
Clin Case Rep. 2017 Sep 8;5(10):1701-1705. doi: 10.1002/ccr3.1124. eCollection
2017 Oct. PubMed PMID: 29026576; PubMed Central PMCID: PMC5628249.
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2: Abramavicius S, Velickiene D, Kadusevicius E. Methimazole-induced liver injury
overshadowed by methylprednisolone pulse therapy: Case report. Medicine
(Baltimore). 2017 Sep;96(39):e8159. doi: 10.1097/MD.0000000000008159. PubMed
PMID: 28953662; PubMed Central PMCID: PMC5626305.
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3: Mancano MA. ISMP Adverse Drug Reactions: Levofloxacin-Induced Neuroexcitation
and Hallucinations; Statin-Induced Muscle Rupture; Mefloquine-Induced
Rhabdomyolysis; Methimazole-Induced Cholestatic Hepatitis; Decitabine-Induced
Hand and Foot Syndrome. Hosp Pharm. 2017 May;52(5):330-333. doi:
10.1177/0018578717715349. Epub 2017 May 1. PubMed PMID: 28804147; PubMed Central
PMCID: PMC5551641.

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4: Tatara MR, Go&#322;yński M, Radzki RP, Bieńko M, Krupski W. Effects of long-term
oral administration of methimazole on femur and tibia properties in male Wistar
rats. Biomed Pharmacother. 2017 Oct;94:124-128. doi:
10.1016/j.biopha.2017.07.107. Epub 2017 Jul 28. PubMed PMID: 28759749.
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5: Emre S, Ozdemir D, Orhun S, Kalkan G, Sener S. A case of severe erythema
nodosum induced by methimazole. Saudi Pharm J. 2017 Jul;25(5):813-815. doi:
10.1016/j.jsps.2016.11.003. Epub 2016 Nov 12. PubMed PMID: 28725155; PubMed
Central PMCID: PMC5506710.
<br>

6: Choi HS, Yoo WS. Free Thyroxine, Anti-Thyroid Stimulating Hormone Receptor
Antibody Titers, and Absence of Goiter Were Associated with Responsiveness to
Methimazole in Patients with New Onset Graves/’ Disease. Endocrinol Metab (Seoul).
2017 Jun;32(2):281-287. doi: 10.3803/EnM.2017.32.2.281. PubMed PMID: 28685517;
PubMed Central PMCID: PMC5503874.

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7: Song R, Lin H, Chen Y, Zhang X, Feng W. Effects of methimazole and
propylthiouracil exposure during pregnancy on the risk of neonatal congenital
malformations: A meta-analysis. PLoS One. 2017 Jul 3;12(7):e0180108. doi:
10.1371/journal.pone.0180108. eCollection 2017. PubMed PMID: 28671971; PubMed
Central PMCID: PMC5495385.
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8: Kim HJ, Bang JI, Kim JY, Moon JH, So Y, Lee WW. Novel Application of
Quantitative Single-Photon Emission Computed Tomography/Computed Tomography to
Predict Early Response to Methimazole in Graves/’ Disease. Korean J Radiol. 2017
May-Jun;18(3):543-550. doi: 10.3348/kjr.2017.18.3.543. Epub 2017 Apr 3. PubMed
PMID: 28458607; PubMed Central PMCID: PMC5390624.

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9: Wei Q, Hu B, Xue Y, Mburu DK, Tao X, Su J. Effects of methimazole on
Drosophila glucolipid metabolism in vitro and in vivo. Comp Biochem Physiol C
Toxicol Pharmacol. 2017 Jun;196:54-60. doi: 10.1016/j.cbpc.2017.03.011. Epub 2017
Mar 21. PubMed PMID: 28341216.

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10: Gaspar-da-Costa P, Duarte Silva F, Henriques J, do Vale S, Braz S, Meneses
Santos J, M M Victorino R. Methimazole associated eosinophilic pleural effusion:
a case report. BMC Pharmacol Toxicol. 2017 Mar 21;18(1):16. doi:
10.1186/s40360-017-0121-1. PubMed PMID: 28320470; PubMed Central PMCID:
PMC5360045.

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