CAS No.: 1190215-03-2
Inquire M2 ion channel blocker (cas: 1190215-03-2 ) online by filling out the inquiry form, we will get back to you within 24 hours!
For research use only. Not Intended for Therapeutic Use!
|Description:||This compound is capable of inhibiting and blocking the activity of M2 ion channel. Antiviral agents. .|
We would like to match the lowest price on market if possible.
This compound is capable of inhibiting and blocking the activity of M2 ion channel. Antiviral agents.
|Product-Name:||M2 ion channel blocker|
. Zhang, Wenjuan; Xu, Jing; Liu, Fang. Heterodimers of histidine and amantadine as inhibitors for wild type and mutant M2 channels of influenza A. Chinese Journal of Chemistry (2010), 28(8), 1417-1423.
Inhibitors bearing the imidazole, adamantane and related structures were synthesized and tested against WT, S31N and S31N-L26I mutant M2 channels. Although amantadine (1) only inhibited WT M2 channel, compd. 6 contg. the imidazole and adamantane groups showed good inhibitory activity to WT and mutant M2 channels. The stereochem. and basic pKa of α-amine are important for the activity of inhibitors and our data showed that derivs. of natural histidine are more active for M2 channels than those of unnatural histidine. The significance of our present results is that we have established a prospective strategy of drug discovery of WT and mutant M2 channels against influenza A…