LGD-2226

• CAT Number: R036606
• CAS Number: 328947-93-9
• Molecular Formula: C14H9F9N2O
• Molecular Weight: 392.225
• Purity: ≥95%
• Target: androgen receptor modulator
• Storage: -20°C
• IUPAC Name: 6-[bis(2,2,2-trifluoroethyl)amino]-4-(trifluoromethyl)-1H-quinolin-2-one
• InChI: InChI=1S/C14H9F9N2O/c15-12(16,17)5-25(6-13(18,19)20)7-1-2-10-8(3-7)9(14(21,22)23)4-11(26)24-10/h1-4H,5-6H2,(H,24,26)
• InChIKey: ULBPQWIGZUGPHU-UHFFFAOYSA-N
• SMILES: C1=CC2=C(C=C1N(CC(F)(F)F)CC(F)(F)F)C(=CC(=O)N2)C(F)(F)F

LGD-2226(CAT: R036606) is a derivative of quinolinone. As an oral selective androgen receptor agonist, LGD-2226 has anabolic effects in both muscle and bone tissue and is currently used to treat diseases such as muscle atrophy and osteoporosis. This product is used in organic synthesis, pharmaceutical research and development, and other scientific research fields.

Reference

1: Hong MH, Sun H, Jin CH, Chapman M, Hu J, Chang W, Burnett K, Rosen J,
Negro-Vilar A, Miner JN. Cell-specific activation of the human skeletal
alpha-actin by androgens. Endocrinology. 2008 Mar;149(3):1103-12. Epub 2007 Dec
6. PubMed PMID: 18063690.
2: Thevis M, Kohler M, Maurer J, Schlörer N, Kamber M, Schänzer W. Screening for
2-quinolinone-derived selective androgen receptor agonists in doping control
analysis. Rapid Commun Mass Spectrom. 2007;21(21):3477-86. PubMed PMID: 17985352.
3: van Oeveren A, Motamedi M, Mani NS, Marschke KB, López FJ, Schrader WT,
Negro-Vilar A, Zhi L. Discovery of 6-N,N-bis(2,2,2-trifluoroethyl)amino-
4-trifluoromethylquinolin-2(1H)-one as a novel selective androgen receptor
modulator. J Med Chem. 2006 Oct 19;49(21):6143-6. PubMed PMID: 17034117.
4: Miner JN, Chang W, Chapman MS, Finn PD, Hong MH, López FJ, Marschke KB, Rosen
J, Schrader W, Turner R, van Oeveren A, Viveros H, Zhi L, Negro-Vilar A. An
orally active selective androgen receptor modulator is efficacious on bone,
muscle, and sex function with reduced impact on prostate. Endocrinology. 2007
Jan;148(1):363-73. Epub 2006 Oct 5. PubMed PMID: 17023534.