Isoproterenol

• CAT Number: I007383
• CAS Number: 7683-59-2
• Molecular Formula: C11H17NO3
• Molecular Weight: 211.261
• Purity: ≥95%
• Solubility: Soluble in DMSO, not in water
• Storage: 0 - 4°C for short term , or -20°C for long term.
• IUPAC Name: 4-[1-hydroxy-2-(propan-2-ylamino)ethyl]benzene-1,2-diol
• InChI: InChI=1S/C11H17NO3/c1-7(2)12-6-11(15)8-3-4-9(13)10(14)5-8/h3-5,7,11-15H,6H2,1-2H3
• InChIKey: JWZZKOKVBUJMES-UHFFFAOYSA-N
• SMILES: CC(C)NCC(C1=CC(=C(C=C1)O)O)O

Isoproterenol (Cat No.:I007383) is a beta-adrenergic receptor excitatory drug, mainly used in bronchial asthma, toxic shock, cardiac arrest (drowning, anesthesia accident, sinus node failure, etc.) and atrioventricular block.

Reference

1:In vivo and molecular docking studies using whole extract and phytocompounds of Aegle marmelos fruit protective effects against Isoproterenol-induced Myocardial infarction in rats. Krushna GS, Shivaranjani VL, Umamaheswari J, Srinivasulu C, Hussain SA, Kareem MA, Reddy VD, Ali D, Lokhande KB, Swamy KV, Kodidhela LD.Biomed Pharmacother. 2017 May 12;91:880-889. doi: 10.1016/j.biopha.2017.04.115. [Epub ahead of print] PMID: 28511341 2:Trace Element Determination and Cardioprotection of Terminalia pallida Fruit Ethanolic Extract in Isoproterenol Induced Myocardial Infarcted Rats by ICP-MS. Althaf Hussain S, Kareem MA, Rasool SN, Al Omar SY, Saleh A, Al-Fwuaires MA, Daddam JR, Devi KL.Biol Trace Elem Res. 2017 May 15. doi: 10.1007/s12011-017-1037-8. [Epub ahead of print] PMID: 28508188 3:Stachydrine ameliorates isoproterenol-induced cardiac hypertrophy and fibrosis by suppressing inflammation and oxidative stress through inhibiting NF-κB and JAK/STAT signaling pathways in rats. Zhao L, Wu D, Sang M, Xu Y, Liu Z, Wu Q.Int Immunopharmacol. 2017 May 9;48:102-109. doi: 10.1016/j.intimp.2017.05.002. [Epub ahead of print] PMID: 28499193 4:Astaxanthin Prevented Oxidative Stress in Heart and Kidneys of Isoproterenol-Administered Aged Rats. Alam MN, Hossain MM, Rahman MM, Subhan N, Mamun MAA, Ulla A, Reza HM, Alam MA.J Diet Suppl. 2017 May 10:1-13. doi: 10.1080/19390211.2017.1321078. [Epub ahead of print] PMID: 28489954 5:Cardioprotective Effects of Malvidin Against Isoproterenol-Induced Myocardial Infarction in Rats: A Mechanistic Study. Wei H, Li H, Wan SP, Zeng QT, Cheng LX, Jiang LL, Peng YD.Med Sci Monit. 2017 Apr 26;23:2007-2016. PMID: 28445445 Free PMC Article6:In vivo ameliorative effect of cerium oxide nanoparticles in isoproterenol-induced cardiac toxicity. El Shaer SS, Salaheldin TA, Saied NM, Abdelazim SM.Exp Toxicol Pathol. 2017 Apr 18. pii: S0940-2993(17)30032-5. doi: 10.1016/j.etp.2017.03.001. [Epub ahead of print] PMID: 28431810 7:Retraction of: abstract P71, In vitro and in vivo direct monitoring of miRNA-22 expression in isoproterenol-induced cardiac hypertrophy by bioluminescence imaging. Tu Y, Wan L, Bu L, Shen B.Cardiovasc Res. 2017 Feb 1;113(2):248. doi: 10.1093/cvr/cvu244. No abstract available. PMID: 28415131 8:Comprehensive metabonomic analysis of heart tissue from isoproterenol-induced myocardial infarction rat based on reversed-phase and hydrophilic interaction chromatography coupled to mass spectrometry. Sun L, Liu J, Sun M, Lin L, Miao L, Ge Z, Yang B.J Sep Sci. 2017 Mar 29. doi: 10.1002/jssc.201601013. [Epub ahead of print] PMID: 28371309 9:Aqueous extract from leaf of Artocarpus altilis provides cardio-protection from isoproterenol induced myocardial damage in rats: Negative chronotropic and inotropic effects. Nwokocha C, Palacios J, Simirgiotis MJ, Thomas J, Nwokocha M, Young L, Thompson R, Cifuentes F, Paredes A, Delgoda R.J Ethnopharmacol. 2017 May 5;203:163-170. doi: 10.1016/j.jep.2017.03.037. Epub 2017 Mar 22. PMID: 28342858 10:KLF15 protects against isoproterenol-induced cardiac hypertrophy via regulation of cell death and inhibition of Akt/mTOR signaling. Gao L, Guo Y, Liu X, Shang D, Du Y.Biochem Biophys Res Commun. 2017 May 20;487(1):22-27. doi: 10.1016/j.bbrc.2017.03.087. Epub 2017 Mar 20. PMID: 28336438