IR-780 Iodide

• CAT Number: I029490
• CAS Number: 207399-07-3
• Molecular Formula: C36H44ClIN2
• Molecular Weight: 667.12
• Purity: 98%
• Solubility: Soluble in methanol
• Storage: Store at -20°C
• IUPAC Name: 2-[2-[2-Chloro-3-[(1,3-dihydro-3,3-dimethyl-1-propyl-2H-indol-2-ylidene)ethylidene]-1-cyclohexen-1-yl]ethenyl]-3,3-dimethyl-1-propylindolium iodide
• InChI: InChI=1S/C36H44ClN2.HI/c1-7-24-38-30-18-11-9-16-28(30)35(3,4)32(38)22-20-26-14-13-15-27(34(26)37)21-23-33-36(5,6)29-17-10-12-19-31(29)39(33)25-8-2;/h9-12,16-23H,7-8,13-15,24-25H2,1-6H3;1H/q+1;/p-1
• InChIKey: IRPKBYJYVJOQHQ-UHFFFAOYSA-M
• SMILES: CC1(C)C(/C=C/C2=C(Cl)/C(CCC2)=C/C=C3N(CCC)C4=C(C=CC=C4)C3(C)C)=[N+](CCC)C5=C1C=CC=C5.[I-]

IR-780 Iodide (Cat No.:I029490) is a cyanine dye used in biomedical applications. It is a near-infrared fluorescent dye that enables deep-tissue imaging. With strong absorption and emission in the near-infrared range, it allows non-invasive visualization of tissues and organs. IR-780 Iodide also possesses photothermal therapy potential, where it can generate localized heat upon near-infrared light exposure, making it useful for targeted cancer treatment.

Reference

1: Li S, Zhou S, Li Y, Li X, Zhu J, Fan L, Yang S. Exceptionally High Payload of the IR780 Iodide on Folic Acid-Functionalized Graphene Quantum Dots for Targeted Photothermal Therapy. ACS Appl Mater Interfaces. 2017 Jul 12;9(27):22332-22341. doi: 10.1021/acsami.7b07267. Epub 2017 Jun 28. PubMed PMID: 28643511.
2: Zhan Y, Liu Y, Zu H, Guo Y, Wu S, Yang H, Liu Z, Lei B, Zhuang J, Zhang X, Huang D, Hu C. Phase-controlled synthesis of molybdenum oxide nanoparticles for surface enhanced Raman scattering and photothermal therapy. Nanoscale. 2018 Mar 29;10(13):5997-6004. doi: 10.1039/c8nr00413g. PubMed PMID: 29542776.
3: Nagy-Simon T, Potara M, Craciun AM, Licarete E, Astilean S. IR780-dye loaded gold nanoparticles as new near infrared activatable nanotheranostic agents for simultaneous photodynamic and photothermal therapy and intracellular tracking by surface enhanced resonant Raman scattering imaging. J Colloid Interface Sci. 2018 May 1;517:239-250. doi: 10.1016/j.jcis.2018.02.007. Epub 2018 Feb 3. PubMed PMID: 29428811.