Indoxyl Sulfate-d5 potassium salt - CAS 1644451-34-2

Indoxyl sulfate-d5 is intended for use as an internal standard for the quantification of indoxyl sulfate by GC- or LC-MS. Indoxyl sulfate is a uremic toxin and a metabolite of tryptophan. It is formed via sulfation of indole, an intermediate generated from tryptophan by intestinal bacteria, by the sulfotransferase (SULT) isoform 1A1 variant 2 (SULT1A1*2) in the liver. Indoxyl sulfate activates the aryl hydrocarbon receptor (AhR) in HepG2 40/6 hepatoma cells (EC50 = 12.1 nM in a reporter assay). It also inhibits the organic anion transporter (OAT) isoforms OAT1 and OAT3 (Kis = 34.2 and 74.4 µM, respectively for the rat transporters) in S2 proximal tubule cells. Indoxyl sulfate (0.2 and 1 mM) increases superoxide anion and nitric oxide levels in isolated human mononuclear blood cells. It increases serum creatinine and blood urea nitrogen (BUN) levels in the 5/6 nephrectomized rat model of chronic renal failure when administered at a dose of 50 mg/kg.

Catalog Number: I029357

CAS Number: 1644451-34-2

Molecular Formula: C8HD5KNO4S

Molecular Weight:256.3278

Purity: 98.0%

Appearance:Solid powder

* For research use only. Not for human or veterinary use.

Synonym

SynonymsIndoxyl Sulfate-d5 potassium salt; Indoxyl Sulfate d5 potassium salt;

Property

Molecular Formula: C8HD5KNO4S
Molecular Weight256.3278
SolubilityTo be determined
Purity98.0%
StorageDry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Computed Descriptor

IUPAC Namepotassium 1H-indol-3-yl-2,4,5,6,7-d5 sulfate
InChIInChI=1S/C8H7NO4S.K/c10-14(11,12)13-8-5-9-7-4-2-1-3-6(7)8;/h1-5,9H,(H,10,11,12);/q;+1/p-1/i1D,2D,3D,4D,5D;
InChIKeyMDAWATNFDJIBBD-GWVWGMRQSA-M
SMILES[O-]S(OC1=C(NC2=C(C([2H])=C(C([2H])=C21)[2H])[2H])[2H])(=O)=O.[K+]