IKK-16 HCl - CAS 1186195-62-9 (HCl salt)

IKK-16 is a potent and slective inhibitor of IκB kinase (IKK) (IC50 values are 40, 70 and 200 nM for IKKβ, IKK complex and IKKα respectively). KK-16 inhibits TNFα-stimulated expression of the adhesion molecules E-selectin, ICAM-1, and VCAM-1 in HUVEC cells.

Catalog Number: I007271

CAS Number: 1186195-62-9 (HCl salt)

Molecular Formula: C28H30ClN5OS

Molecular Weight:520.092

Purity: ≥95%

* For research use only. Not for human or veterinary use.

Synonym

SynonymsIKK-16; IKK 16; IKK16; IKK-16 HCl;(4-((4-(benzo[b]thiophen-2-yl)pyrimidin-2-yl)amino)phenyl)(4-(pyrrolidin-1-yl)piperidin-1-yl)methanone hydrochloride

Property

Molecular Formula: C28H30ClN5OS
Molecular Weight520.092
SolubilitySoluble in DMSO, not in water
Purity≥95%
Storage0 - 4°C for short term , or -20°C for long term.
IC5040nM

Computed Descriptor

SMILESO=C(C1=CC=C(NC2=NC=CC(C3=CC4=CC=CC=C4S3)=N2)C=C1)N5CCC(N6CCCC6)CC5.[H]Cl