ID33

ID33 is a Potent Tubulin Polymerization Inhibitor. ID33 showed excellent aqueous solubility and favorable Log P value and displayed noteworthily low nanomolar potency against a variety of tumor cells, including those taxol-resistant ones. ID33 inhibited tubulin polymerization, disrupted cellular microtubule networks by targeting the colchicine site, and promoted HepG2 cell cycle arrest and cell apoptosis. In the HepG2 xenograft mouse model.

Catalog Number: I029175

Molecular Formula: C23H31Cl2N5O3

Molecular Weight:496.433

Purity: 98.0%

Appearance:Solid powder

* For research use only. Not for human or veterinary use.

Synonym

SynonymsID33; ID 33; ID-33;

Property

Molecular Formula: C23H31Cl2N5O3
Molecular Weight496.433
SolubilitySoluble in DMSO
Purity98.0%
StorageDry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Computed Descriptor

IUPAC Name7-(3-aminopropoxy)-6-ethoxy-N-(6-ethoxypyridin-2-yl)-1-methyl-1,4-dihydroindeno[1,2-c]pyrazol-3-amine dihydrochloride
InChIInChI=1S/C23H29N5O3.2ClH/c1-4-29-18-13-15-12-17-22(16(15)14-19(18)31-11-7-10-24)28(3)27-23(17)26-20-8-6-9-21(25-20)30-5-2;;/h6,8-9,13-14H,4-5,7,10-12,24H2,1-3H3,(H,25,26,27);2*1H
InChIKeyQUKLDSQNXVICSW-UHFFFAOYSA-N
SMILESCN1N=C(NC2=NC(OCC)=CC=C2)C3=C1C4=C(C=C(OCC)C(OCCCN)=C4)C3.[H]Cl.[H]Cl