GYKI-23107 is an antiarrhythmic agent with local anaesthetic activity. GYKI-23107 was effective against chemically (aconitine and ouabain) induced arrhythmias after both parenteral and oral administration. GYKI-23107 and mexiletine produced similar elevation of the fibrillation threshold in anaesthetized cats. After oral pretreatment, GYKI-23107 showed protective effects against coronary ligation-induced arrhythmia in conscious rats. The circulatory side-effects of GYKI-23107 in anaesthetized and conscious dogs and cats were milder then those of mexiletine.
GYKI-23107; GYKI 23107; GYKI23107; GYKI-23,107; GYKI 23,107; GYKI23,107; GYKI-23107 HCl.;N1-(2,6-dimethylphenyl)-N2,N2-dimethylpropane-1,2-diamine dihydrochloride
|Storage::||0 - 4°C for short term , or -20°C for long term.|
We would like to match the lowest price on market if possible.
For research use only. Not Intended for Therapeutic Use!
|Cas No:||83843-39-4 (HCl); 83843-49-6 (free base).|
1: Varró A, Németh M, Rabloczky G, Papp JG, Szekeres L. Electrophysiological effects of GYKI-23 107, a new antiarrhythmic compound, in isolated rabbit and canine cardiac preparations. J Cardiovasc Pharmacol. 1988 Mar;11(3):251-7. PubMed PMID: 2452917.