GSK2141795 hydrochloride - CAS 1047635-80-2
GSK2141795 Hcl is a potent and selective pan-Akt inhibitor with IC50 values of 180 nM for Akt1, 328 nM for Akt2, and 38 nM for Akt3 respectively (Clinical phase 1).
IC50 value: 180/328/38 nM (Akt1/2/3)
Target: pan-Akt inhibitor
KD values of 16 nM for Akt1, 49 nM for Akt2, and 5 nM for Akt3 (for GSK2141795), which are in line with literature data from biochemical assays that report potencies of 2 nM for Akt1, 2-13 nM for Akt2, and 3-9 nM Akt3 for GSK690693.
Catalog Number: I000264
CAS Number: 1047635-80-2
PubChem Substance ID:355039227
Molecular Formula: C18H17Cl3F2N4O2
Molecular Weight:465.71
Purity: ≥95%
* For research use only. Not for human or veterinary use.
Synonym
Synonyms | N-((S)-1-amino-3-(3,4-difluorophenyl)propan-2-yl)-5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)furan-2-carboxamide hydrochloride |
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Property
Molecular Formula: | C18H17Cl3F2N4O2 |
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Molecular Weight | 465.71 |
Target: | Akt |
Solubility | 10 mM in DMSO |
Purity | ≥95% |
Storage | Store at -20C |
IC50 | 180/328/38 nM (Akt1/2/3) |