Gallamine Triethiodide

• CAT Number: A000240
• CAS Number: 65-29-2
• Molecular Formula: C30H60I3N3O3
• Molecular Weight: 891.53
• Purity: ≥95%
• Target: AChR
• Solubility: Soluble in DMSO > 10 mM
• Storage: -20°C
• InChI: 1S/C30H60N3O3.3HI/c1-10-31(11-2,12-3)22-25-34-28-20-19-21-29(35-26-23-32(13-4,14-5)15-6)30(28)36-27-24-33(16-7,17-8)18-9;;;/h19-21H,10-18,22-27H2,1-9H3;3*1H/q+3;;;/p-3
• InChIKey: REEUVFCVXKWOFE-UHFFFAOYSA-K
• SMILES: CC[N+](CC)(CC)CCOC1=C(C(=CC=C1)OCC[N+](CC)(CC)CC)OCC[N+](CC)(CC)CC.[I-].[I-].[I-]

Gallamine Triethiodide is a mAChR M2 antagonist with pronounced cardioselectivity. It acts by combining with the cholinergic receptor sites in muscle and competitively blocks the transmitter action of acetylcholine. It is a synthetic non-depolarizing blocking drug. The actions of gallamine triethiodide are similar to those of tubocurarine but this agent blocks the cardiac vagus and may cause sinus tachycardia and, occasionally, hypertension and increased cardiac output.

Reference

1: Abbas MN, Mostafa GA. Gallamine-tetraphenylborate-modified carbon paste
electrode for the potentiometric determination of gallamine triethiodide
(flaxedil). J Pharm Biomed Anal. 2003 Mar 26;31(4):819-26. PubMed PMID: 12644209.

2: Hinck D, Wulff H, Koppenhöfer E. Gallamine triethiodide selectively blocks
voltage-gated potassium channels in Ranvier nodes. Gen Physiol Biophys. 2001
Mar;20(1):83-95. PubMed PMID: 11508824.

3: Ali AM, Ghandour MA, Abd-El-Fattah MM. Cathodic adsorptive stripping
voltammetric determination of muscle relaxant: gallamine triethiodide (flaxedil).
J Pharm Biomed Anal. 2001 Apr;25(1):31-7. PubMed PMID: 11274856.

4: Al-Jafari AA. The inhibitory effect of the neuromuscular blocking agent,
gallamine triethiodide, on camel retina acetylcholinesterase activity. Toxicol
Lett. 1997 Jan 15;90(1):45-51. PubMed PMID: 9020401.

5: Pain YZ, Wang LH, Tang YH, Yin XM, Wang S. [Antagonistic effect of
electro-acupuncture analgesia with Ca2+ injection into habenula could be reversed
by gallamine triethiodide]. Sheng Li Xue Bao. 1992 Aug;44(4):326-32. Chinese.
PubMed PMID: 1293745.

6: Harrison JF, Bird AG. Anaphylaxis to precurarising doses of gallamine
triethiodide. Anaesthesia. 1986 Jun;41(6):600-4. PubMed PMID: 3728928.

7: Schauf CL, Smith KJ. Gallamine triethiodide-induced modifications of sodium
conductance in Myxicola giant axons. J Physiol. 1982 Feb;323:157-71. PubMed PMID:
6284914; PubMed Central PMCID: PMC1250350.

8: Smith KJ, Schauf CL. Gallamine triethiodide (flaxedil): tetraethylammonium-
and pancuronium-like effects in myelinated nerve fibers. Science. 1981 Jun
5;212(4499):1170-2. PubMed PMID: 7233212.

9: Smith KJ, Schauf CL. Effects of gallamine triethiodide on membrane currents in
amphibian and mammalian peripheral nerve. J Pharmacol Exp Ther. 1981
Jun;217(3):719-26. PubMed PMID: 6971929.

10: Ramzan IM, Shanks CA, Triggs EJ. Pharmacokinetics and pharmacodynamics of
gallamine triethiodide in patients with total biliary obstruction. Anesth Analg.
1981 May;60(5):289-96. PubMed PMID: 7194593.