Fluorofenidone

• CAT Number: I017969
• CAS Number: 848353-85-5
• Molecular Formula: C₁₂H₁₀FNO
• Molecular Weight: 203.21
• Purity: ≥95%

Fluorofenidone(CAT: I017969) is a chemical compound with potential therapeutic applications. It is an analog of AMR69 and has been found to exhibit antifibrotic activity, particularly in the context of renal interstitial fibrosis. Fluorofenidone’s beneficial effects include the attenuation of renal fibrosis progression. It achieves this by targeting specific cellular mechanisms. One of its actions involves the suppression of NADPH oxidase, an enzyme complex associated with the production of reactive oxygen species (ROS) and oxidative stress. Additionally, Fluorofenidone is involved in reducing the deposition of extracellular matrix (ECM), which is a key factor in fibrotic tissue remodeling.

Reference

[1]. Qin J, et al. Fluorofenidone inhibits nicotinamide adeninedinucleotide phosphate oxidase via PI3K/Akt pathway in the pathogenesis of renal interstitial fibrosis. Nephrology (Carlton). 2013 Oct;18(10):690-9.[2]. Lou Q, et al. Design, synthesis and antifibrotic activities of carbohydrate-modified 1-(substituted aryl)-5-trifluoromethyl-2(1H) pyridones. Molecules. 2012 Jan 17;17(1):884-96.