FLI-06 - CAS 313967-18-9

FLI-06 is a novel potent and selective small molecule intercepting Notch signaling and the early secretory pathway (EC50 ~2.3 μM), identified by using automated microscopy to monitor the trafficking and processing of a ligand-independent Notch-GFP fusion reporter.
IC50 value: 2.3 uM (EC50) [1]
Target: Notch signaling
FLI-06 can induce accumulation of the reporter at the plasma membrane by interfering with transport in the secretory pathway. It can also disrupt the Golgi apparatus in a manner distinct from that of brefeldin A and golgicide A. FLI-06 inhibited general secretion at a step before exit from the endoplasmic reticulum (ER), which was accompanied by a tubule-to-sheet morphological transition of the ER, rendering FLI-06 the first small molecule acting at such an early stage in secretory traffic. FLI-06 is a very useful chemical probe to study the inhibition of membrane traffic at pre- ER-exit site (ERES) stages without fusion of ER-Golgi.

Catalog Number: I003113

CAS Number: 313967-18-9

PubChem Substance ID:355049757

Molecular Formula: C₂₅H₃₀N₂O₅

Molecular Weight:438.52

Purity: ≥95%

* For research use only. Not for human or veterinary use.

Synonym

Synonymscyclohexyl 2,7,7-trimethyl-4-(4-nitrophenyl)-5-oxo-1,4,6,8-tetrahydroquinoline-3-carboxylate

Property

Molecular Formula: C₂₅H₃₀N₂O₅
Molecular Weight438.52
Target:Notch
SolubilityDMSO: ≥ 38 mg/mL
Purity≥95%
StorageStore at -20 C
IC502.3 uM (EC50) [1]

Computed Descriptor

InChIInChI=1S/C25H30N2O5/c1-15-21(24(29)32-18-7-5-4-6-8-18)22(16-9-11-17(12-10-16)27(30)31)23-19(26-15)13-25(2,3)14-20(23)28/h9-12,18,22,26H,4-8,13-14H2,1-3H3
InChIKeySWWVFYHSSOWZMF-UHFFFAOYSA-N
SMILESCC1(C)CC(C(C(C2=CC=C([N+]([O-])=O)C=C2)C(C(OC3CCCCC3)=O)=C(C)N4)=C4C1)=O