Ethynodiol diacetate

  • CAT Number: A001129
  • CAS Number: 297-76-7
  • Molecular Formula: C24H32O4
  • Molecular Weight: 384.51
  • Purity: ≥95%
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Etynodiol diacetate is a steroidal progestin which is used as a hormonal contraceptive. Relative to other 19-nortestosterone derivatives, it has relatively little or no potency as an androgen, and, unlike most progestins but similarly to noretynodrel, also has some estrogenic effects.

Catalog Number A001129
CAS Number 297-76-7
Molecular Formula

C24H32O4

Purity 95%
Target Estrogen/progestogen Receptor
Solubility >19.2mg/mL in DMSO
Storage 3 years -20C powder
Reference

</br>1:Biotransformation of oral contraceptive ethynodiol diacetate with microbial and plant cell cultures. Zafar S, Yousuf S, Kayani HA, Saifullah, Khan S, Al-Majid AM, Choudhary MI.Chem Cent J. 2012 Sep 29;6(1):109. doi: 10.1186/1752-153X-6-109. PMID: 23021311 Free PMC Article</br>2:Protective role of nordihydroguaiaretic acid (NDGA) against the genotoxic damage induced by ethynodiol diacetate in human lymphocytes in vitro. Siddique YH, Ara G, Beg T, Afzal M.J Environ Biol. 2007 Apr;28(2):279-82. PMID: 17915765 </br>3:Estimation of impurity profiles of drugs and related materials: part XXI. HPLC/UV/MS study of the impurity profile of ethynodiol diacetate. Babják M, Balogh G, Gazdag M, Görög S.J Pharm Biomed Anal. 2002 Aug 1;29(6):1153-7. PMID: 12110402 </br>4:Influence of Ethynodiol Diacetate on the Formation of A-Homo-3Oxa-5?-Pregnane-4,20-Dione in Female Rats. Simic B, Kniewald J, Kniewald Z.Endocr Regul. 1998 Sep;32(3):125-131. PMID: 10196509 </br>5:Incidence of ovarian cyst formation in women taking ethynodiol diacetate, 1 mg, with ethinyl estradiol, 35 micrograms. Friedman AJ, Wheeler JM.J Reprod Med. 1991 Apr;36(4 Suppl):345-9. PMID: 2046084 </br>6:Complexion changes in oral contraceptive users. Results from a phase IV multicenter trial evaluating the safety and efficacy of ethynodiol diacetate, 1 mg, with ethinyl estradiol, 35 micrograms. Wheeler JM, Malinak LR.J Reprod Med. 1991 Apr;36(4 Suppl):340-4. PMID: 2046083 </br>7:Efficacy and safety of ethynodiol diacetate, 1 mg, with ethinyl estradiol, 35 micrograms, with an emphasis on contraceptive efficacy. A phase IV trial. Friedman AJ, Wheeler J.J Reprod Med. 1991 Apr;36(4 Suppl):328-33. PMID: 2046081 </br>8:Safety and efficacy of ethynodiol diacetate, 1 mg, plus ethinyl estradiol, 35 micrograms. A phase IV trial. Introduction. Friedman AJ.J Reprod Med. 1991 Apr;36(4 Suppl):323-4. No abstract available. PMID: 2046079 </br>9:[Analysis of steroids. Part 40. Isolation and identification of unusual impurities in ethynodiol diacetate]. Görög S, Halmos Z, Herényi B, Georgakis A, Balogh G, Csizér E, Tuba Z.Acta Pharm Hung. 1991 Mar;61(2):77-81. Hungarian. PMID: 1887802 </br>10:Clinical experience with ethynodiol diacetate 0.5 mg daily as an oral contraceptive. Shroff NE, Pearce MY, Stratford ME, Wilkinson PD.Contraception. 1987 Feb;35(2):121-34. PMID: 3297483

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