EPZ020411 HCl - CAS 1700663-41-7 (free base)

EPZ020411 is a potent and selective PRMT6 inhibitor tool compound. PRMT6 overexpression has been reported in several cancer types suggesting that inhibition of PRMT6 activity may have therapeutic utility. Identification of EPZ020411 provides the field with the first small molecule tool compound for target validation studies. EPZ020411 shows good bioavailability following subcutaneous dosing in rats making it a suitable tool for in vivo studies.

Catalog Number: I006696

CAS Number: 1700663-41-7 (free base)

Molecular Formula: C25H40Cl2N4O3

Molecular Weight:515.52

Purity: ≥95%

* For research use only. Not for human or veterinary use.

Synonym

SynonymsEPZ020411; EPZ-020411; EPZ 020411; EPZ020411 HCl; EPZ020411 hydrochloride;N1,N2-dimethyl-N1-((3-(4-((1r,3r)-3-(2-(tetrahydro-2H-pyran-4-yl)ethoxy)cyclobutoxy)phenyl)-1H-pyrazol-4-yl)methyl)ethane-1,2-diamine dihydrochloride

Property

Molecular Formula: C25H40Cl2N4O3
Molecular Weight515.52
SolubilitySoluble in DMSO, not in water
Purity≥95%
Storage0 - 4°C for short term or -20 °C for long term

Computed Descriptor

SMILESCNCCN(C)CC1=CNN=C1C2=CC=C(O[C@H]3C[C@H](OCCC4CCOCC4)C3)C=C2.[H]Cl.[H]Cl