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ENMD-2076

ENMD-2076

  • CAT Number: I006675
  • CAS Number: 934353-76-1
  • Molecular Formula: C₂₁H₂₅N₇
  • Molecular Weight: 375.47
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ENMD-2076 (Cat No.:I006675) is an orally available, biologically effective multi-targeted kinase inhibitor that includes anti-proliferative, pro-apoptotic activity, and anti-angiogenic efficacy.ENMD-2076 selectively acts on Aurora A and VEGFR (Flt3) with IC50 values of 14 nM and 1.86 nM, respectively, and also inhibits the growth of various human solid tumor and hematopoietic cancer cell lines with IC50 values of 0.025 to 0.7 μM, and induced apoptosis and G2/M phase arrest.

Catalog Number I006675
CAS Number 934353-76-1
Molecular Formula

C₂₁H₂₅N₇

Purity 95%
Target Aurora Kinase
Solubility Soluble in DMSO, not in water
Storage 3 years -20C powder
Related CAS 1291074-87-7 (tartrate)
InChI InChI=1S/C21H25N7/c1-16-14-20(26-25-16)23-19-15-21(28-12-10-27(2)11-13-28)24-18(22-19)9-8-17-6-4-3-5-7-17/h3-9,14-15H,10-13H2,1-2H3,(H2,22,23,24,25,26)/b9-8+
InChIKey BLQYVHBZHAISJM-CMDGGOBGSA-N
SMILES CC1=CC(=NN1)NC2=NC(=NC(=C2)N3CCN(CC3)C)C=CC4=CC=CC=C4

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