EGF816 - CAS 1508250-71-2

EGF816 is a novel covalent inhibitor of mutant-selective EGFR; overcomes T790M-mediated resistance in NSCLC.

Catalog Number: I001869

CAS Number: 1508250-71-2

PubChem Substance ID:355038228

Molecular Formula: C26H31ClN6O2

Molecular Weight:495.0

Purity: ≥95%

* For research use only. Not for human or veterinary use.

Synonym

Synonyms(R,E)-N-(7-chloro-1-(1-(4-(dimethylamino)but-2-enoyl)azepan-3-yl)-1H-benzo[d]imidazol-2-yl)-2-methylisonicotinamide

Property

Molecular Formula: C26H31ClN6O2
Molecular Weight495.0
Target:EGFR
SolubilityDMSO: ≥ 242 mg/mL
Purity≥95%
StorageStore at -20°C

Computed Descriptor

InChIInChI=1S/C26H31ClN6O2/c1-18-16-19(12-13-28-18)25(35)30-26-29-22-10-6-9-21(27)24(22)33(26)20-8-4-5-15-32(17-20)23(34)11-7-14-31(2)3/h6-7,9-13,16,20H,4-5,8,14-15,17H2,1-3H3,(H,29,30,35)/b11-7+/t20-/m1/s1
InChIKeyIOMMMLWIABWRKL-WUTDNEBXSA-N
SMILESO=C(/C=C/CN(C)C)N1CCCC[C@@H](N2C(NC(C3=CC=NC(C)=C3)=O)=NC4=C2C(Cl)=CC=C4)C1