Dorsomorphin dihydrochloride

• CAT Number: I013941
• CAS Number: 1219168-18-9
• Molecular Formula: C₂₄H₂₇Cl₂N₅O
• Molecular Weight: 472.41
• Purity: ≥95%
• Target: AMPKAutophagy
• Solubility: H2O: ≥ 48 mg/mL; DMSO: 5.2 mg/mL (Need ultrasonic)
• Storage: under inert gas (nitrogen or Argon) at 2-8°C
• IUPAC Name: 6-[4-(2-piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine;dihydrochloride
• InChI: InChI=1S/C24H25N5O.2ClH/c1-2-12-28(13-3-1)14-15-30-22-6-4-19(5-7-22)21-16-26-24-23(17-27-29(24)18-21)20-8-10-25-11-9-20;;/h4-11,16-18H,1-3,12-15H2;2*1H
• InChIKey: RJDVIJJQKMGPMV-UHFFFAOYSA-N
• SMILES: C1CCN(CC1)CCOC2=CC=C(C=C2)C3=CN4C(=C(C=N4)C5=CC=NC=C5)N=C3.Cl.Cl

Dorsomorphin dihydrochloride (Cat No.:I013941), also known as BML-275,Compound C, is a potent, reversible, selective AMPK inhibitor with a Ki of 109 nM in a cell-free assay that also inhibits type I BMP receptors.Dorsomorphin also induces autophagy in cancer cell lines.

Reference

[1]. Zhou G, et al. Role of AMP-activated protein kinase in mechanism of metformin action. J Clin Invest. 2001 Oct;108(8):1167-74.[2]. Saito S, et al. Compound C prevents the unfolded protein response during glucose deprivation through a mechanism independent of AMPK and BMP signaling. PLoS One. 2012;7(9):e45845.[3]. Yu PB, et al. Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism. Nat Chem Biol. 2008 Jan;4(1):33-41.[4]. Zhang DY, et al. Role of autophagy and its molecular mechanisms in mice intestinal tract after severe burn. J Trauma Acute Care Surg. 2017 Oct;83(4):716-724.