Dofetilide

• CAT Number: A000803
• CAS Number: 115256-11-6
• Molecular Formula: C₁₉H₂₇N₃O₅S₂
• Molecular Weight: 441.56
• Purity: ≥95%
• Target: Potassium Channel
• Solubility: >21.2mg/mL in DMSO
• Storage: -20°C
• InChI: InChI=1S/C19H27N3O5S2/c1-22(13-12-16-4-6-17(7-5-16)20-28(2,23)24)14-15-27-19-10-8-18(9-11-19)21-29(3,25)26/h4-11,20-21H,12-15H2,1-3H3
• InChIKey: IXTMWRCNAAVVAI-UHFFFAOYSA-N
• SMILES: CN(CCC1=CC=C(C=C1)NS(=O)(=O)C)CCOC2=CC=C(C=C2)NS(=O)(=O)C

Dofetilide is a class III antiarrhythmic agent.

Reference

1: Ibrahim MA, Bhimji SS. Dofetilide. 2017 Oct 23. StatPearls [Internet].
Treasure Island (FL): StatPearls Publishing; 2017 Jun-. Available from
http://www.ncbi.nlm.nih.gov/books/NBK459154/
PubMed PMID: 29083831.

2: Carstensen H, Kjær L, Haugaard MM, Flethøj M, Hesselkilde EZ, Kanters JK,
Pehrson S, Buhl R, Jespersen T. Antiarrhythmic Effects of Combining Dofetilide
and Ranolazine in a Model of Acutely Induced Atrial Fibrillation in Horses. J
Cardiovasc Pharmacol. 2017 Oct 25. doi: 10.1097/FJC.0000000000000541. [Epub ahead
of print] PubMed PMID: 29068807.

3: Briceño DF, Supple GE. Dofetilide Reloaded: To Admit or Not to Admit, That is
the Question. Circ Arrhythm Electrophysiol. 2017 Oct;10(10). pii: e005815. doi:
10.1161/CIRCEP.117.005815. PubMed PMID: 29038110.

4: Cho JH, Youn SJ, Moore JC, Kyriakakis R, Vekstein C, Militello M, Poe SM,
Wolski K, Tchou PJ, Varma N, Niebauer MJ, Bhargava M, Saliba WI, Wazni OM,
Lindsay BD, Wilkoff BL, Chung MK. Safety of Oral Dofetilide Reloading for
Treatment of Atrial Arrhythmias. Circ Arrhythm Electrophysiol. 2017 Oct;10(10).
pii: e005333. doi: 10.1161/CIRCEP.117.005333. PubMed PMID: 29038104; PubMed
Central PMCID: PMC5685174.

5: Rickard JP, Negrelli J, Olson JL, Dick T. Frequency of Adverse Event
Monitoring in Ambulatory Patients on Amiodarone or Dofetilide. J Pharm Pract.
2017 Jan 1:897190017729523. doi: 10.1177/0897190017729523. [Epub ahead of print]
PubMed PMID: 28884613.

6: Britton OJ, Abi-Gerges N, Page G, Ghetti A, Miller PE, Rodriguez B.
Quantitative Comparison of Effects of Dofetilide, Sotalol, Quinidine, and
Verapamil between Human Ex vivo Trabeculae and In silico Ventricular Models
Incorporating Inter-Individual Action Potential Variability. Front Physiol. 2017
Aug 18;8:597. doi: 10.3389/fphys.2017.00597. eCollection 2017. PubMed PMID:
28868038; PubMed Central PMCID: PMC5563361.

7: VanderLugt JT, Bon C, Knuth D, Schreiber R, Ruff MD. Pharmacokinetics and
Bioequivalence of Branded and Generic Formulations of Dofetilide 0.5-mg Capsules
After Single-Dose Administration in Healthy Subjects. Clin Pharmacol Drug Dev.
2017 Aug 11. doi: 10.1002/cpdd.371. [Epub ahead of print] PubMed PMID: 28800211.

8: Alsaad AA, Silvers SM, Kusumoto F, Blackshear JL. Dofetilide-induced torsade
de pointes in high-grade atrioventricular node dysfunction. Postgrad Med J. 2017
Oct;93(1104):635-636. doi: 10.1136/postgradmedj-2017-134933. Epub 2017 Jun 29.
PubMed PMID: 28663351.

9: Liu G, Xue X, Gao C, Huang J, Qi D, Zhang Y, Dong JZ, Ma CS, Yan GX.
Synergistic Effect of Dofetilide and Mexiletine on Prevention of Atrial
Fibrillation. J Am Heart Assoc. 2017 May 18;6(5). pii: e005482. doi:
10.1161/JAHA.117.005482. PubMed PMID: 28522677; PubMed Central PMCID: PMC5524094.

10: Hassan Virk HU, Qureshi WT, Makkar N, Bastawrose J, Souvaliotis N, Aziz J,
Aziz E. Short- and long-term clinical predictors of pharmacological cardioversion
of persistent atrial fibrillation by dofetilide: A retrospective cohort study of
160 patients. Clin Cardiol. 2017 Jul;40(7):474-479. doi: 10.1002/clc.22680. Epub
2017 Mar 14. PubMed PMID: 28295387.