Cyclosporine A - CAS 59865-13-3
Cyclosporine A, also known as cyclosporine, is a natural cyclic polypeptide immunosuppressant isolated from the fungus Beauveria nivea. The exact mechanism of action of cyclosporine is not known but may involve binding to the cellular protein cytophilin, resulting in inhibition of the enzyme calcineurin. This agent appears to specifically and reversibly inhibit immunocompetent lymphocytes in the G0-or G1-phase of the cell cycle. T-lymphocytes are preferentially inhibited with T-helper cells as the primary target. Cyclosporine also inhibits lymphokine production and release.
Catalog Number: A000634
CAS Number: 59865-13-3
PubChem Substance ID:355038518
Molecular Formula: C₆₂H₁₁₁N₁₁O₁₂
Molecular Weight:1202.6
Purity: ≥95%
* For research use only. Not for human or veterinary use.
Synonym
Synonyms | Ciclosporin; Cyclosporine; Neoral; Ciclosporine; Cyclosporin |
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Property
Molecular Formula: | C₆₂H₁₁₁N₁₁O₁₂ |
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Molecular Weight | 1202.6 |
Purity | ≥95% |
Storage | -20°C |
MDL | MFCD00274558 |
Computed Descriptor
InChI | InChI=1S/C62H111N11O12/c1-25-27-28-40(15)52(75)51-56(79)65-43(26-2)58(81)67(18)33-48(74)68(19)44(29-34(3)4)55(78)66-49(38(11)12)61(84)69(20)45(30-35(5)6)54(77)63-41(16)53(76)64-42(17)57(80)70(21)46(31-36(7)8)59(82)71(22)47(32-37(9)10)60(83)72(23)50(39(13) |
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InChIKey | PMATZTZNYRCHOR-CGLBZJNRSA-N |
SMILES | CCC1C(=O)N(CC(=O)N(C(C(=O)NC(C(=O)N(C(C(=O)NC(C(=O)NC(C(=O)N(C(C(=O)N(C(C(=O)N(C(C(=O)N(C(C(=O)N1)C(C(C)CC=CC)O)C)C(C)C)C)CC(C)C)C)CC(C)C)C)C)C)CC(C)C)C)C(C)C)CC(C)C)C)C |