Cloxacillin Sodium

• CAT Number: A000983
• CAS Number: 7081-44-9
• Molecular Formula: C19H19ClN3NaO6S
• Molecular Weight: 475.88
• Purity: ≥95%
• Storage: 3 years -20C powder

Cloxacillin sodium is a narrow spectrum β-lactam antibiotic of the penicillin class. Cloxacillin sodium is freely soluble in aqueous solution (0.014 mg/mL).β-lactams interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to β-lactams is commonly due to cells containing plasmid encoded β-lactamases. Unlike other members of the penicillin class, cloxacillin is resistant to β-lactamases.

Reference

Guzmán, Flavio, MD. /Beta Lactams Antibiotics (penicillins and Cephalosporins) Mechanism of Action.” Medical Pharmacology. Pharmacology Corner, 29 Nov. 2008. Web. 21 Aug. 2012.Pitout JD, Sanders CC, Sanders WE Jr. Antimicrobial resistance with focus on beta-lactam resistance in gram-negative bacilli. Am J Med 1997; 103:51.