CLOFLUBICYNE - CAS 224790-70-9
This is a potent non-competitive GABA antagonist, a convulsant and a laboratory insecticide.
Organofluorate compound11H6F6N2Cl2–>, synthetic
The IC50 for blocking the GABA-dependent [36Cl] uptake in rat brain synaptosomes: 10 nM. The inhibition of the GABA-dependent Cl- current occurs at 5.3 nM.<br>
Experiments with [3H]-labelled GABA-competitive ligands (Muscimol, Flunitrazepam) showed no influence of Cloflubicyne up to 10 μM.
Catalog Number: T000127
CAS Number: 224790-70-9
PubChem Substance ID:355155653
Molecular Formula: C11H6Cl2F6N2
Molecular Weight:351.073
Purity: ≥95%
* For research use only. Not for human or veterinary use.
Property
| Molecular Formula: | C11H6Cl2F6N2 |
|---|---|
| Molecular Weight | 351.073 |
| Solubility | In alcohol, alcohol + water and acetone |
| Purity | ≥95% |
| Storage | Store at room temperature.<br> 1 mg Cloflubicyne can be dissolved in 1 ml ethanol (up to 50 C), then diluted in distilled water. Solution for experiments must contain less than 0.5 % ethanol and be stored at 0 C. |
Computed Descriptor
| IUPAC Name | 5,6-dichloro-3,3-bis(trifluoromethyl)bicyclo[2.2.1]heptane-2,2-dicarbonitrile |
|---|---|
| InChI | InChI=1S/C11H6Cl2F6N2/c12-6-4-1-5(7(6)13)9(10(14,15)16,11(17,18)19)8(4,2-20)3-21/h4-7H,1H2 |
| InChIKey | NTESZNJQNKSALM-UHFFFAOYSA-N |
| SMILES | C1C2C(C(C1C(C2(C#N)C#N)(C(F)(F)F)C(F)(F)F)Cl)Cl |