CLOFLUBICYNE - CAS 224790-70-9

This is a potent non-competitive GABA antagonist, a convulsant and a laboratory insecticide.

Organofluorate compound11H6F6N2Cl2–>, synthetic

The IC50 for blocking the GABA-dependent [36Cl] uptake in rat brain synaptosomes: 10 nM. The inhibition of the GABA-dependent Cl- current occurs at 5.3 nM.<br>
Experiments with [3H]-labelled GABA-competitive ligands (Muscimol, Flunitrazepam) showed no influence of Cloflubicyne up to 10 &mu;M.

Catalog Number: T000127

CAS Number: 224790-70-9

PubChem Substance ID:355155653

Molecular Formula: C11H6Cl2F6N2

Molecular Weight:351.073

Purity: ≥95%

* For research use only. Not for human or veterinary use.


Molecular Formula: C11H6Cl2F6N2
Molecular Weight351.073
SolubilityIn alcohol, alcohol + water and acetone
StorageStore at room temperature.<br> 1 mg Cloflubicyne can be dissolved in 1 ml ethanol (up to 50 C), then diluted in distilled water. Solution for experiments must contain less than 0.5 % ethanol and be stored at 0 C.

Computed Descriptor

IUPAC Name5,6-dichloro-3,3-bis(trifluoromethyl)bicyclo[2.2.1]heptane-2,2-dicarbonitrile