Ciclopirox

• CAT Number: A000768
• CAS Number: 29342-05-0
• Molecular Formula: C12H17NO2
• Molecular Weight: 207.3
• Purity: ≥95%
• Target: ATPase
• Storage: 3 years -20C powder
• IUPAC Name: 6-cyclohexyl-1-hydroxy-4-methylpyridin-2-one
• InChI: InChI=1S/C12H17NO2/c1-9-7-11(13(15)12(14)8-9)10-5-3-2-4-6-10/h7-8,10,15H,2-6H2,1H3
• InChIKey: SCKYRAXSEDYPSA-UHFFFAOYSA-N
• SMILES: CC1=CC(=O)N(C(=C1)C2CCCCC2)O

Ciclopirox (CAS 29342-05-0) is a broad-spectrum antifungal agent working as an iron chelator.
Ciclopirox olamine (CPX) is a lipophilic bidentate iron chelator that stabilizes HIF-1alpha under normoxic conditions at lower concentrations than other iron chelators, probably by inhibiting HIF-1alpha hydroxylation. Ciclopirox olamine (CPX)-induced HIF-1 mediates reporter gene activity and endogenous HIF-1 target gene expression, including elevation of transcription, mRNA, and protein levels of the vascular endothelial growth factor (VEGF).

Overview of Clinical Research

Ciclopirox is a cell cycle inhibitor, DNA repair inhibitor and DNA synthesis inhibitor. It has been granted for the new molecular entity. 

Reference

1.Łowicki, Daniel, and Adam Huczyński. "Structure and antimicrobial properties of monensin A and its derivatives: summary of the achievements." BioMed research international 2013 (2013).
2.Baby, Santhosh M., et al. "Effects of hypoxia and intracellular iron chelation on hypoxia-inducible factor-1α and-1β in the rat carotid body and glomus cells." Histochemistry and cell biology 120.5 (2003): 343-352.