Chlormezanone

  • CAT Number: A000807
  • CAS Number: 80-77-3
  • Molecular Formula: C11H12ClNO3S
  • Molecular Weight: 273.74
  • Purity: ≥95%
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Chlormezanone is a non-benzodiazepine that is used in the management of anxiety. Chlormezanone is a skeletal muscle relaxant, acting at the benzodiazepine site of GABAA receptors. Chlormezanone is a substrate of GABA receptor. It has been suggested for use in the treatment of muscle spasm.

Catalog Number A000807
CAS Number 80-77-3
Molecular Formula

C11H12ClNO3S

Purity 95%
Storage -20°C
InChI InChI=1S/C11H12ClNO3S/c1-13-10(14)6-7-17(15,16)11(13)8-2-4-9(12)5-3-8/h2-5,11H,6-7H2,1H3
InChIKey WEQAYVWKMWHEJO-UHFFFAOYSA-N
SMILES CN1C(S(=O)(=O)CCC1=O)C2=CC=C(C=C2)Cl
Reference

1: Chen ZR, Chen LM, Du SM. [Determination of chlormezanone in serum by gas
chromatography]. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2012
May;30(5):391-2. Chinese. PubMed PMID: 22804998.
<br>

2: Yan S, Li HZ, Zhang XY, Li HJ. [Retrospective analysis of the combined therapy
of terazosin with chlormezanone for chronic prostatitis/chronic pelvic pain
syndrome]. Zhonghua Nan Ke Xue. 2009 Aug;15(8):717-20. Chinese. PubMed PMID:
19852273.
<br>

3: Wollina U, Hipler UC, Seeling A, Oelschlager H. Investigations of interactions
of chlormezanone racemate and its enantiomers on human keratinocytes and human
leucoytes in vitro. Skin Pharmacol Physiol. 2005 May-Jun;18(3):132-8. PubMed
PMID: 15897685.
<br>

4: Oelschl&#228;ger H, Wange J, Letsch J, Seeling A. [New findings on the synthesis of
the centrally acting muscle relaxant chlormezanone and its resolution of a gram
scale using a Chiralcel OD column]. Pharmazie. 2003 Feb;58(2):95-8. German.
PubMed PMID: 12641322.

<br>
5: Sarrá S. [Acute confusional syndrome associated to chlormezanone]. Rev Med
Chil. 2002 Nov;130(11):1317-8. Spanish. PubMed PMID: 12587517.
<br>

6: Miranda M, Venegas P, Kagi M. [Acute confusional syndrome associated to
Chlormezanone use]. Rev Med Chil. 2002 Jun;130(6):707-8. Spanish. PubMed PMID:
12194698.
<br>

7: Seeling A, Oelschl&#228;ger H, Rothley D. [Important pharmaceutical-chemical
characteristics of the central muscle relaxant chlormezanone]. Pharmazie. 2000
Apr;55(4):293-6. German. PubMed PMID: 10798243.
<br>

8: Klinger W, Oelschl&#228;ger H, Rothley D, Karge E, Seeling A. Interaction of
chlormezanone enantiomers with rat liver microsomes. Eur J Drug Metab
Pharmacokinet. 1999 Jan-Mar;24(1):63-8. PubMed PMID: 10412893.

<br>
9: Mehta U. Withdrawal of chlormezanone-containing products. S Afr Med J. 1999
Feb;89(2):137. PubMed PMID: 10191862.
<br>

10: Oelschl&#228;ger H, Klinger W, Rothley D, Seeling A, Bockhard H, Hofmann B, Machts
H, Riederer H, Rackur H. [Cleavage and biotransformation of the central muscle
relaxant chlormezanone]. Pharmazie. 1998 Sep;53(9):620-4. German. PubMed PMID:
9770210.

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