Chk2 Inhibitor

• CAT Number: I003862
• CAS Number: 516480-79-8
• Molecular Formula: C₂₀H₁₄CIN₃O₂
• Molecular Weight: 363.8
• Purity: ≥95%
• Target: Chk
• Solubility: DMSO: ≥ 55 mg/mL
• Storage: Store at -20℃
• IC50: 15 nM [1]
• IUPAC Name: 2-[4-(4-chlorophenoxy)phenyl]-3H-benzimidazole-5-carboxamide
• InChI: InChI=1S/C20H14ClN3O2/c21-14-4-8-16(9-5-14)26-15-6-1-12(2-7-15)20-23-17-10-3-13(19(22)25)11-18(17)24-20/h1-11H,(H2,22,25)(H,23,24)
• InChIKey: UXGJAOIJSROTTN-UHFFFAOYSA-N
• SMILES: C1=CC(=CC=C1C2=NC3=C(N2)C=C(C=C3)C(=O)N)OC4=CC=C(C=C4)Cl

Chk2 inhibitor (Cat.No:I003862) is a compound that specifically targets and inhibits the activity of the protein kinase Chk2 (checkpoint kinase 2). Chk2 is involved in the cellular response to DNA damage and plays a critical role in cell cycle regulation and DNA repair. Inhibition of Chk2 can potentially enhance the effectiveness of DNA-damaging therapies, such as radiation and chemotherapy, in cancer treatment.

Reference

[1]. Arienti KL, et al. Checkpoint kinase inhibitors: SAR and radioprotective properties of a series of 2-arylbenzimidazoles. J Med Chem. 2005 Mar 24;48(6):1873-85.