Cefazolin Sodium

• CAT Number: A000075
• CAS Number: 27164-46-1
• Molecular Formula: C14H13N8O4S3 • Na
• Molecular Weight: 476.5
• Purity: ≥95%
• Target: Antibiotic
• Solubility: Soluble in DMSO
• Storage: Store at -20°C
• InChIKey: FLKYBGKDCCEQQM-WYUVZMMLSA-M

Cefazolin sodium is a first generation cephalosporin antibiotic.  Cefazolin sodium is sparingly soluble in aqueous solution (0.47 mg/mL).Like β-lactams, cephalosporins interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to cephalosporins is commonly due to cells containing plasmid encoded β-lactamases.

Reference

Georgopapadakou, N. H. /Mechanisms of Action of Cephalosporin 3/’-quinolone Esters, Carbamates, and Tertiary Amines in Escherichia Coli./ American Society for Microbiology 37.3 (1992): 559-65. Antimicrobial Agents and Chemotherapy. Web. 21 Aug. 2012.