CAY10606 - CAS 1159576-98-3

5-Lipoxygenase (5-LO) initiates the synthesis of leukotrienes (LTs) from arachidonic acid, primarily in certain leukocyte populations. CAY10606 is a potent, reversible inhibitor of 5-LO, both in cell-free assays (IC50 = 86 nM) and in intact neutrophils (IC50 = 230 nM). It prevents the production of LTs in whole blood, whether 5-LO is activated with the calcium ionophore A23187 (IC50 = 1.6 μM) or formyl peptide (fMLP) following priming with lipopolysaccharide (IC50 = 830 nM). In rats subjected to carrageenan-induced pleurisy, CAY10606 significantly reduces both LT biosynthesis and the inflammatory reaction.

Catalog Number: R064459

CAS Number: 1159576-98-3

PubChem Substance ID:355153832

Molecular Formula: C22H18ClNO3

Molecular Weight:379.84

Purity: ≥95%

* For research use only. Not for human or veterinary use.

Synonym

Synonyms2-[(3-chlorophenyl)methyl]-5-hydroxy-1H-benz[g]indole-3-carboxylic acid, ethyl ester

Property

Molecular Formula: C22H18ClNO3
Molecular Weight379.84
Purity≥95%
Storage-20°C

Computed Descriptor

IUPAC Nameethyl 2-[(3-chlorophenyl)methyl]-5-hydroxy-1H-benzo[g]indole-3-carboxylate
InChIInChI=1S/C22H18ClNO3/c1-2-27-22(26)20-17-12-19(25)15-8-3-4-9-16(15)21(17)24-18(20)11-13-6-5-7-14(23)10-13/h3-10,12,24-25H,2,11H2,1H3
InChIKeyUNDGVXYIMIZWAS-UHFFFAOYSA-N
SMILESCCOC(=O)C1=C(NC2=C1C=C(C3=CC=CC=C32)O)CC4=CC(=CC=C4)Cl