Carbenicillin

• CAT Number: I003627
• CAS Number: 4697-36-3
• Molecular Formula: C17H18N2O6S
• Molecular Weight: 378.4
• Purity: ≥95%
• Target: Antibiotic
• Solubility: water: 833 mg/ml;alcohol: 40 mg/ml; Insoluble in chloroform, and acetone
• Storage: Store at -20C

Carbenicillin is broad-spectrum semisynthetic penicillin derivative used parenterally.Target: AntibacterialCarbenicillin is a semi-synthetic penicillin antibiotic which interferes with cell wall synthesis of gram-negative bacteria while displaying low toxicity. The leukocytes of the patients does not release histamine on in vitro provocation with Carbenicillin (0.1 g/mL). Carbenicillin (0.1 g/mL) does not show any allergic drug reactions in cystic fibrosis patients, as evident by no significant levels of antibodies of IgE, IgG or IgM classes [1]. Carbenicillin (50 μg/mL) results in phytotoxicity in chrysanthemum and TOB, with an increase in the concentration, and with a parallel shift in the morphogenic capacity (SRC) of threshold survival levels (TSLs). Carbenicillin results in 100% acclimatization with no different morphological flowering characteristics following subculture in vitro three times in Chrysanthemum plantlets [2].

Reference

1:Effect of tannic and gallic acids alone or in combination with carbenicillin or tetracycline on Chromobacterium violaceum CV026 growth, motility, and biofilm formation. Dusane DH, O/’May C, Tufenkji N.Can J Microbiol. 2015 Jul;61(7):487-94. Epub 2015 Jun 3. PMID: 26039903 2:A response regulator from a soil metagenome enhances resistance to the β-lactam antibiotic carbenicillin in Escherichia coli. Allen HK, An R, Handelsman J, Moe LA.PLoS One. 2015 Mar 17;10(3):e0120094. doi: 10.1371/journal.pone.0120094. eCollection 2015. PMID: 25782011 Free PMC Article3:A polythiophene-derived ratiometric fluorescent sensor for highly sensitive determination of carbenicillin in aqueous solution. Lan M, Liu W, Ge J, Wu J, Wang H, Zhang W, Bi Y, Wang P.Chem Commun (Camb). 2012 Jul 11;48(54):6818-20. doi: 10.1039/c2cc32910g. Epub 2012 May 30. PMID: 22648337 4:Inactivation of MuxABC-OpmB transporter system in Pseudomonas aeruginosa leads to increased ampicillin and carbenicillin resistance and decreased virulence. Yang L, Chen L, Shen L, Surette M, Duan K.J Microbiol. 2011 Feb;49(1):107-14. doi: 10.1007/s12275-011-0186-2. Epub 2011 Mar 3. PMID: 21369987 5:Highly selective recognition of carbenicillin via concerted interactions in 100% aqueous solution. Zeng L, Liu W, Zhuang X, Wu J, Wang P, Zhang W.Chem Commun (Camb). 2010 Apr 14;46(14):2435-7. doi: 10.1039/b923318k. Epub 2010 Jan 27. PMID: 20379550 6:Complexation of beta-lactam antibiotic drug carbenicillin to bovine serum albumin: energetics and conformational studies. Thoppil AA, Sharma R, Kishore N.Biopolymers. 2008 Oct;89(10):831-40. doi: 10.1002/bip.21021. PMID: 18488985 7:New carbenicillin-hydrolyzing beta-lactamase (CARB-7) from Vibrio cholerae non-O1, non-O139 strains encoded by the VCR region of the V. cholerae genome. Melano R, Petroni A, Garutti A, Saka HA, Mange L, Pasterán F, Rapoport M, Rossi A, Galas M.Antimicrob Agents Chemother. 2002 Jul;46(7):2162-8. PMID: 12069969 Free PMC Article8:Evaluation of inhibition of the carbenicillin-hydrolyzing beta-lactamase PSE-4 by the clinically used mechanism-based inhibitors. Therrien C, Kotra LP, Sanschagrin F, Mobashery S, Levesque RC.FEBS Lett. 2000 Mar 31;470(3):285-92. PMID: 10745083 Free Article9:Characterization and nucleotide sequence of CARB-6, a new carbenicillin-hydrolyzing beta-lactamase from Vibrio cholerae. Choury D, Aubert G, Szajnert MF, Azibi K, Delpech M, Paul G.Antimicrob Agents Chemother. 1999 Feb;43(2):297-301. PMID: 9925522 Free PMC Article10:Structure of CARB-4 and AER-1 carbenicillin-hydrolyzing beta-lactamases. Sanschagrin F, Bejaoui N, Levesque RC.Antimicrob Agents Chemother. 1998 Aug;42(8):1966-72. PMID: 9687391 Free PMC Article