camalexin

• CAT Number: M130162
• CAS Number: 135531-86-1
• Molecular Formula: C11H8N2S
• Molecular Weight: 200.259
• Purity: ≥95%
• Storage: -20°C
• IUPAC Name: 2-(1H-indol-3-yl)-1,3-thiazole
• InChI: InChI=1S/C11H8N2S/c1-2-4-10-8(3-1)9(7-13-10)11-12-5-6-14-11/h1-7,13H
• InChIKey: IYODIJVWGPRBGQ-UHFFFAOYSA-N
• SMILES: C1=CC=C2C(=C1)C(=CN2)C3=NC=CS3

Camalexin is an alkaloid released by plants of the Brassicaceae family in response to pathogen infection. In addition to antimicrobial properties and a role in plant defense, camalexin exhibits antiproliferative activity in vitro against various cancer cell lines. Camalexin is active against HeLa, Jurkat, MDA-MB-231, and CEM cancer cell lines (IC50s = 50.0, 46.2, 77.7, and 67.6 μM, respectively), but it is also toxic to primary human umbilical vein endothelial cells (HUVEC; (IC50 = 74.0 μM). Camalexin induces apoptosis in Jurkat cells by increasing reactive oxygen species (ROS) levels and activating caspase-8 and caspase-9. In human prostate cancer cell lines, camalexin (25 μM) is more active against aggressive lines and increases ROS levels and apoptosis via cathepsin D relocation from lysosomes to the cytosol.