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Bosentan Hydrate

Bosentan Hydrate

  • CAT Number: A000455
  • CAS Number: 157212-55-0
  • Molecular Formula: C27H31N5O7S
  • Molecular Weight: 569.63
  • Purity: ≥95%
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Bosentan is an endothelin (ET) receptor antagonist for ET-A and ET-B with K<sub>i</sub> of 4.7 nM and 95 nM, respectively.<br>Bosentan competitively antagonizes the specific binding of [<br>Bosentan inhibits the presser response to big ET-1 both after i.v. and oral administration, with a long duration of action and no intrinsic agonist activity. Bosentan also inhibits the depressor and presser effect of ET-1 and sarafotoxin S6C. Its pharmacological profile makes Bosentan a potentially useful drug in the management of clinical disorders associated with vasoconstriction.

Catalog Number A000455
CAS Number 157212-55-0
Molecular Formula

C27H31N5O7S

Purity 95%
Target Endothelin Receptor
Solubility >28.5mg/mL in DMSO
Storage 3 years -20C powder

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