Benztropine mesylate

• CAT Number: A001146
• CAS Number: 132-17-2
• Molecular Formula: C21H25NO • CH3SO3H
• Molecular Weight: 403.5
• Purity: ≥95%
• Target: Histamine Receptor
• Solubility: Soluble in DMSO > 10 mM
• Storage: 3 years -20C powder
• InChI: InChI=1S/C21H25NO.CH4O3S/c1-22-18-12-13-19(22)15-20(14-18)23-21(16-8-4-2-5-9-16)17-10-6-3-7-11-17;1-5(2,3)4/h2-11,18-21H,12-15H2,1H3;1H3,(H,2,3,4)/t18-,19+,20+
• InChIKey: CPFJLLXFNPCTDW-BWSPSPBFSA-N
• SMILES: CN1[C@@H]2C[C@@H](OC(C3=CC=CC=C3)C4=CC=CC=C4)C[C@H]1CC2.OS(C)(=O)=O

Benztropine is a synthetic compound derived from the combination of atropine and diphenhydramine that acts centrally to antagonize M1 muscarinic acetylcholine receptors. Benztropine has been used in the management of Parkinson’s disease symptoms to address involuntary tremor and dystonia. It can also increase the availability of dopamine by inhibiting uptake through the dopamine transporter.

Reference

1:New use of an old drug: inhibition of breast cancer stem cells by benztropine mesylate. Cui J, Hollmén M, Li L, Chen Y, Proulx ST, Reker D, Schneider G, Detmar M.Oncotarget. 2017 Jan 3;8(1):1007-1022. doi: 10.18632/oncotarget.13537. PMID: 27894093 Free PMC Article2:Thrombocytopenia possibly associated with olanzapine and subsequently with benztropine mesylate. Bogunovic O, Viswanathan R.Psychosomatics. 2000 May-Jun;41(3):277-8. No abstract available. PMID: 10849461 3:Compatibility of haloperidol lactate with benztropine mesylate. Jackson CW, Cunningham K.Am J Hosp Pharm. 1994 Dec 1;51(23):2962-3. No abstract available. PMID: 7879808 4:Sinus bradycardia related to the use of benztropine mesylate. Voinov H, Elefante V, Mujica R.Am J Psychiatry. 1992 May;149(5):711. No abstract available. PMID: 1575268 5:Effects of benztropine mesylate on haloperidol-induced prolactin secretion and serum haloperidol levels in rats. Rosenberg JM, Sideman M, Kampa IS, McGuire H, Kampa L.J Pharm Sci. 1984 Dec;73(12):1833-5. PMID: 6527272 6:The withdrawal of benztropine mesylate in chronic schizophrenic patients. Baker LA, Cheng LY, Amara IB.Br J Psychiatry. 1983 Dec;143:584-90. PMID: 6362765 7:Effects of benztropine mesylate (Cogentin) on accommodation in normal volunteers. Thaler JS.Am J Optom Physiol Opt. 1982 Nov;59(11):918-9. No abstract available. PMID: 7180936 8:The effect of benztropine mesylate on the prolactin response to haloperidol. Halbreich U, Sachar EJ, Nathan RS, Asnis GM, Halpern FS.Psychopharmacology (Berl). 1980;72(1):61-5. PMID: 6781007 9:Benztropine mesylate and social anxiety. Rapp MS.Am J Psychiatry. 1979 Dec;136(12):1611. No abstract available. PMID: 507226 10:The effect of benztropine mesylate in the rabbit syndrome and tardive dyskinesia. Sovner R, Dimascio A.Am J Psychiatry. 1977 Nov;134(11):1301-2. No abstract available. PMID: 910992