Benzonatate

• CAT Number: M069983
• CAS Number: 104-31-4
• Molecular Formula: C30H53NO11
• Molecular Weight: 603.75
• Purity: ≥95%
• Target: Sodium Channel Protein Antagonist
• Storage: -20°C
• IUPAC Name: 2-[2-[2-[2-[2-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethyl 4-(butylamino)benzoate
• InChI: InChI=1S/C30H53NO11/c1-3-4-9-31-29-7-5-28(6-8-29)30(32)42-27-26-41-25-24-40-23-22-39-21-20-38-19-18-37-17-16-36-15-14-35-13-12-34-11-10-33-2/h5-8,31H,3-4,9-27H2,1-2H3
• InChIKey: MAFMQEKGGFWBAB-UHFFFAOYSA-N
• SMILES: CCCCNC1=CC=C(C=C1)C(=O)OCCOCCOCCOCCOCCOCCOCCOCCOCCOC

Benzoxamate (Cat. No: M069983) is a peripheral non-addictive antitussive drug. It has a strong local anesthetic effect on respiratory receptors. It has a significant inhibitory effect on pulmonary stretch receptors and sensory nerve endings, inhibits pulmonary vagal reflex, reduces cough impulse afferent, and also has a certain inhibitory effect on the cough center.

Reference

1:Benzonatate Toxicity: Nothing to Cough At. Bishop-Freeman SC, Shonsey EM, Friederich LW, Beuhler MC, Winecker RE.J Anal Toxicol. 2017 Jun 1;41(5):461-463. doi: 10.1093/jat/bkx021. No abstract available. PMID: 28334901 2:A 17-Year-Old Girl With Cough–Pulseless After Drug Overdose. Sodium benzonatate overdose. Yoshioka I, Surmaitis R, Katz KD.Pediatr Emerg Care. 2016 Mar;32(3):197-9. doi: 10.1097/PEC.0000000000000733. No abstract available. PMID: 26928103 3:Benzonatate inhibition of voltage-gated sodium currents. Evans MS, Maglinger GB, Fletcher AM, Johnson SR.Neuropharmacology. 2016 Feb;101:179-87. doi: 10.1016/j.neuropharm.2015.09.020. Epub 2015 Sep 16. PMID: 26386152 4:Analysis of benzonatate overdoses among adults and children from 1969-2010 by the United States Food and Drug Administration. McLawhorn MW, Goulding MR, Gill RK, Michele TM.Pharmacotherapy. 2013 Jan;33(1):38-43. doi: 10.1002/phar.1153. PMID: 23307543 5:Benzonatate toxicity in a teenager resulting in coma, seizures, and severe metabolic acidosis. Thimann DA, Huang CJ, Goto CS, Feng SY.J Pediatr Pharmacol Ther. 2012 Jul;17(3):270-3. doi: 10.5863/1551-6776-17.3.270. PMID: 23258970 Free PMC Article6:Corneal anesthetic abuse from the use of topical benzonatate (Tessalon Perle). Hendershot AJ, Colling L, Mauger TF.Cornea. 2011 Dec;30(12):1518-9. doi: 10.1097/ICO.0b013e318207f229. No abstract available. PMID: 21673569 7:In brief: benzonatate warning. [No authors listed]Med Lett Drugs Ther. 2011 Feb 7;53(1357):9. Review. No abstract available. PMID: 21304443 8:Benzonatate Ingestion Reported to the National Poison Center Database System (NPDS). Winter ML, Spiller HA, Griffith JR.J Med Toxicol. 2010 Dec;6(4):398-402. doi: 10.1007/s13181-010-0086-6. PMID: 20490746 Free PMC Article9:Cardiac arrest with residual blindness after overdose of Tessalon® (benzonatate) perles. Cohen V, Jellinek SP, Stansfield L, Truong H, Baseluos C, Marshall JP.J Emerg Med. 2011 Aug;41(2):166-71. doi: 10.1016/j.jemermed.2009.08.027. Epub 2009 Nov 5. PMID: 19892505 10:Inhibition of cough-reflex sensitivity by benzonatate and guaifenesin in acute viral cough. Dicpinigaitis PV, Gayle YE, Solomon G, Gilbert RD.Respir Med. 2009 Jun;103(6):902-6. doi: 10.1016/j.rmed.2008.12.008. Epub 2009 Jan 1. PMID: 19121573 Free Article