Avibactam sodium - CAS 1192491-61-4

Avibactam (CAS 1192491-61-4), which is the first non-β-lactam β-lactamase inhibitor to be introduced for clinical use, is a broad-spectrum serine β-lactamase inhibitor with activity against class A, class C, and, some, class D β-lactamases. In combination with ceftazidime, Avibactam is a new drug application for avibactam , and was approved by the FDA on February 25, 2015, to treat complicated urinary tract and complicated intra-abdominal Infections caused by antibiotic resistant-pathogens. 

Catalog Number: I003307

CAS Number: 1192491-61-4

PubChem Substance ID:355038153

Molecular Formula: C7H10N3NaO6S

Molecular Weight:287.23

Purity: ≥95%

* For research use only. Not for human or veterinary use.

Synonym

• Synonyms: NXL104; NXL-104; NXL 104; Avibactam; Avibactam sodium.;sodium (2S,5R)-2-carbamoyl-7-oxo-1,6-diazabicyclo[3.2.1]octan-6-yl sulfate

Property

• Molecular Formula: C7H10N3NaO6S
• Molecular Weight: 287.23
• Target: non-β-lactam β-lactamase inhibitor
• Solubility: Soluble in DMSO, not in water
• Purity: ≥95%
• Storage: 0 - 4 °C for short term or -20 °C for long term
• Related CAS.: 1192500-31-4 ( Avibactam free acid)
• Overview of Clinical Research: Avibactam is a beta lactamase inhibitor and a cell wall inhibitor. Antimicrobial data from in vitro studies in Enterobacteriaceae and P. aeruginosa isolates presented at the IDWeek 2020 (IDW-2020)

Computed Descriptor

• IUPAC Name: sodium;[(2S,5R)-2-carbamoyl-7-oxo-1,6-diazabicyclo[3.2.1]octan-6-yl] sulfate
• InChI: InChI=1S/C7H11N3O6S.Na/c8-6(11)5-2-1-4-3-9(5)7(12)10(4)16-17(13,14)15;/h4-5H,1-3H2,(H2,8,11)(H,13,14,15);/q;+1/p-1/t4-,5+;/m1./s1
• InChIKey: RTCIKUMODPANKX-JBUOLDKXSA-M
• SMILES: C1CC(N2CC1N(C2=O)OS(=O)(=O)[O-])C(=O)N.[Na+]