Ascochlorin - CAS 26166-39-2
Ascochlorin is an antitumor fungal metabolite with antitumor and antiviral properties.
Ascochlorin specifically inhibits matrix metalloproteinase-9 (MMP-9) activity through suppression of activator protein-1 (AP-1)-dependent induction of MMP-9 gene expression. Via AP-1 suppression, ascochlorin selectively kills MX-1 cells, a human breast cancer cell line lacking estrogen receptors.
Catalog Number: R003136
CAS Number: 26166-39-2
Molecular Formula: C23H29CIO4
Molecular Weight:404.9
Purity: ≥95%
Appearance:White Powder
* For research use only. Not for human or veterinary use.
Synonym
Synonyms | Antibiotic LL-Z1272γ;Ilicicolin D;NSC 287492 |
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Property
Molecular Formula: | C23H29CIO4 |
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Molecular Weight | 404.9 |
Purity | ≥95% |
Storage | -20°C |
Computed Descriptor
IUPAC Name | 5-chloro-2,4-dihydroxy-6-methyl-3-[(2E,4E)-3-methyl-5-[(1R,2R,6R)-1,2,6-trimethyl-3-oxocyclohexyl]penta-2,4-dienyl]benzaldehyde |
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InChI | InChI=1S/C23H29ClO4/c1-13(10-11-23(5)14(2)7-9-19(26)16(23)4)6-8-17-21(27)18(12-25)15(3)20(24)22(17)28/h6,10-12,14,16,27-28H,7-9H2,1-5H3/b11-10+,13-6+/t14-,16+,23+/m1/s1 |
InChIKey | SETVRSKZJJWOPA-FLDGXQSCSA-N |
SMILES | CC1CCC(=O)C(C1(C)C=CC(=CCC2=C(C(=C(C(=C2O)Cl)C)C=O)O)C)C |