CAS No.: 80-50-2
PubChem Substance ID: 355144679
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For research use only. Not Intended for Therapeutic Use!
(3-endo)-8,8-Dimethyl-3-[(1-oxo-2-propylpentyl)oxy]-8-azoniabicyclo[3.2.1]octane Bromide; 3α-Hydroxy-8-methyl-1αH,5αH-tropanium Bromide 2-Propylvalerate; endo-8,8-Dimethyl-3-[(1-oxo-2-propylpentyl)oxy]- 8-azoniabicyclo[3.2.1]octane Bromide; 8-Methylt
|Description:||Octatropine methylbromide (INN) or anisotropine methylbromide (USAN), trade names Valpin, Endovalpin, Lytispasm and others, is a muscarinic antagonist and antispasmodic. It was introduced to the U.S.|
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Octatropine methylbromide (INN) or anisotropine methylbromide (USAN), trade names Valpin, Endovalpin, Lytispasm and others, is a muscarinic antagonist and antispasmodic. It was introduced to the U.S. market in 1963 as an adjunct in the treatment of peptic ulcer, and promoted as being more specific to the gastrointestinal tract than other anticholinergics. Anisotropine methylbromide is a quaternary ammonium compound. Its use as treatment adjunct in peptic ulcer has been replaced by the use of more effective agents. Depending on the dose, anisotropine methylbromide may reduce the motility and secretory activity of the gastrointestinal system, and the tone of the ureter and urinary bladder and may have a slight relaxant action on the bile ducts and gallbladder. In general, smaller doses of anisotropine methylbromide inhibit salivary and bronchial secretions, sweating, and accommodation; cause dilatation of the pupil; and increase the heart rate. Larger doses are required to decrease motility of the gastrointestinal and urinary tracts and to inhibit gastric acid secretion.
Appearance:Solid powderPurity: > 98%
|IUPAC Name:||[(1R,5S)-8,8-dimethyl-8-azoniabicyclo[3.2.1]octan-3-yl] 2-propylpentanoate;bromide|
1:A double-blind evaluation of the nocturnal antisecretory effects of anisotropine methylbromide in man. Dose response and duration of action studies. Freston JW, Forbes JA.J Clin Pharmacol. 1977 Jan;17(1):29-36. PMID: 13090 2:[Clinical study of the selectivity, tolerance and therapeutic status of anisotropine methylbromide and its combinations (Vapin Complex) in digestive pathology and in spastic changes of the biliary tract]. Abad Iglesias R.Folia Clin Int (Barc). 1973 May;23(5):382-402. Spanish. No abstract available. PMID: 4808337 3:Intestinal sorption of anisotropine methylbromide in the rat. Pfeffer M, Schor JM.J Pharm Sci. 1972 Aug;61(8):1223-7. No abstract available. PMID: 5068340 4:Effects of anisotropine methylbromide (Valpin) and its mixture with sulpyrine on vocalization response and spasm of intestine induced by acetylcholine in dogs. Nakayama K, Taira N, Hashimoto K, Kobayashi S, Kumakura S.Jpn J Pharmacol. 1972 Apr;22(2):215-20. No abstract available. PMID: 4538412 Free Article5:[Anisotropine methylbromide (Valpin) in the treatment of spasms of the gastrointestinal system. Biometric study]. Giovannelli CA, Vigo PL.Minerva Med. 1970 Dec 22;61(102):5942-51. Italian. No abstract available. PMID: 5498741 6:[Trials with anisotropine methylbromide (Valpin) in the radiography of the stomach]. Kanda K.Rinsho Hoshasen. 1968 Dec;13(12):1013-9. Japanese. No abstract available. PMID: 5191267 7:Human urinary excretion of the quaternary ammonium compounds anisotropine methylbromide and propantheline bromide. Pfeffer M, Schor JM, Bolton S, Jacobsen R.J Pharm Sci. 1968 Aug;57(8):1375-8. No abstract available. PMID: 5695651 8:Human urinary excretion of orally administered anisotropine methylbromide. Pfeffer M, Schor JM, Gluck N, Semmel MG, Griboff S.J Pharm Sci. 1968 Jan;57(1):36-8. No abstract available. PMID: 5694710 9:The effect of anisotropine methylbromide on human saliva flow and gastric secretion. Stiel JN, Baxter CH.Med J Aust. 1967 May 27;1(21):1076-8. No abstract available. PMID: 6071739 10:The effect of anisotropine methylbromide on bladder function. (A clinical study). Bonney WW, Kaufman JJ.West Med Med J West. 1967 Feb;8(2):40-1. No abstract available. PMID: 6072160