TEMPOXIME


CAS No. : 63467-53-8

TEMPOXIME,63467-53-8
Product Details
Cat No:T000145
Synonyms:2,2,6,6-tetramethylpiperidone-4 oxime hydrochloride.
Molecular Formula:C9H19ClN2O
Molecular Weight:206.714
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Melting Point:~266 °C (decomp.).
Appearance:colorless crystal powder.
Purity:min. 98%.
TLC [Silufol UV-254, MeOH:NH3(25%) Rf = 0.69, development with Dragendorff� reagent]; NMR (D2O).
Cat No:T000145
Cas No:63467-53-8
Product-Name:TEMPOXIME
IUPAC Name:N-(2,2,6,6-tetramethylpiperidin-4-ylidene)hydroxylamine;hydrochloride
InChI:InChI=1S/C9H18N2O.ClH/c1-8(2)5-7(10-12)6-9(3,4)11-8;/h11-12H,5-6H2,1-4H3;1H
InChIKey:PMDFGKBTEGXYED-UHFFFAOYSA-N
SMILES:CC1(CC(=NO)CC(N1)(C)C)C.Cl

a neuronal nicotinic AChR antagonist. Potent ganglioblocker. Hypotensive. Good penetration of biological membranes. Secondary analog of Pempoxime. Antioxidant, radical scavenger.


Piperidine derivative,, synthetic.

For comparative information see the attached 3 tables.

Cell permeant central nicotinic acetylcholine receptor blocker without action on skeleton muscle innervation.

Good to moderate penetration of biological membranes.
Antioxidant (precursor of stable TEMPO nitroxyl radical): together with PEMPOXIME can be used for testing the possibility of antioxydant contribution into any observed biological activity of TEMPOXIME.

Potential antimitotic (ask for the TEMPIDONE data).


- Brehteric et al., Nature (1959). 184:1707-1709

- Lutz et al., J. Org. Chem. (1962) 27(5):1695-1703

- Akhmedkhodzhaeva Kh.S. et al. in Farmakol. alkaloidov ikh proizvod., 1972, Ed. Sultanov M.B., Fan, Tashkent, USSR. 156-162

- Vezen A.E. et al., Dokl. Akad. Nauk Tadzh.SS (1985). CA 104:122584. 28 (6): 350-351



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