TEMPIDINE


CAS No. : 768-66-1 (base), 935-22-8 (HCl).

TEMPIDINE,768-66-1 (base), 935-22-8 (HCl).
Product Details
Cat No:T000143
Synonyms:2,2,6,6-tetramethylpiperidine hydrochloride.
Molecular Formula:C9H19N.HCl
Molecular Weight:177.71 Da.
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Melting Point:299-301 °C.
Appearance:colorless crystal powder.
Purity:min. 98%.
TLC (Silufol UV-254, MeOH:NH3(25%) Rf 0.26, development with Dragendorff� reagent); NMR (D2O).
Cat No:T000143
Cas No:768-66-1 (base), 935-22-8 (HCl).
Product-Name:TEMPIDINE

a neuronal nicotinic AChR antagonist. Potent ganglioblocker. Hypotensive. Good penetration of biological membranes. Secondary analog of Pempidine and Temechine. Antioxidant, radical scavenger.


Piperidine derivative,, synthetic.

For comparative information see the attached 4 tables.
Cell permeant central nicotinic acetylcholine receptor blocker without action on skeleton muscle innervation [1-5].

Antioxidant (precursor of stable TEMPO nitroxyl radical): together with PEMPIDINE can be used for testing the possibility of antioxydant contribution into any observed biological activity of TEMPIDINE.

Potential antimitotic (ask for the TEMPIDONE data).


- Brehteric et al., Nature (1959). 184:1707-1709

- Lee et al., Nature (1958). 181:1717

- Spinks et al., Nature (1959). 181:1397

- Tichonenko V.M., Farm.Toxikol. (1962). 25(6): 689-705

- Filipport E. et al., Arch. Int. Pharmacod. Ther. (1962). 135(3-4):273-280

- Hall H.K., Jr., JACS (1957). 79(20): 5444-5447



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