PENETRAN Cl


CAS No. :

PENETRAN Cl,
Product Details
Cat No:T000137
Synonyms:Z-2-((3/'chlorophenyl)methylene]-3-quinuclidon HCl;
Z-2-[(3/'-chlorophenyl)methylene]-3-oxoquinuclidine HCl
Molecular Formula:C14H14NOCl .HCl synthetic.
Molecular Weight:284.18 Da.
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Melting Point:185-187 °C.
Appearance:slightly yellowish crystal powder.
Purity:min. 99.5%.
TLC [Silufol UV-254, MeOH:NH3(25%) Rf =0.68, development in UV light followed with Dragendorff� reagent]; NMR (D2O).
Cat No:T000137
Product-Name:PENETRAN Cl

an inhibitor of high-affinity choline uptake (HAChU) in synaptosomes; acetylcholine synthesis inhibitor; good penetration of biological membranes.


Quinicludine derivative,

Cell permeable inhibitor of high-affinity choline uptake (HAChU). For comparative information see the attached table.
good penetration of biological membranes.


- Dahlbom R. et al., /Cell Mol. Basis Cholinergic Funct./, Dowdall M. J. and Hawthorne J. N. Eds., Horwood, Chichester U.K., (1987) 347-354

- Sterling et al., /Inhibition of high-affinity choline uptake and acetylcholine synthesis by quinuclidinyl and hemicholinium derivatives/, J. Neurochem.(1986). 46(14):1170-1175

- Doukas P.H. et al., ibid, 355-360

- Baltzod F. et al., Biochem. Pharm. (1980). 29(18):2413-2416

- Tamaru M. et al., Brain Res (1988). 473(2):205-226

- Dowdall M.J. et al., in Cholinergic mechanisms and Psycopharmacology, Ed. D.J.Jenden, Plenum Press, N-Y, (1978). 359



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