VERATROYLZYGADENINE


CAS No. : 31329-58-5

VERATROYLZYGADENINE,31329-58-5
Product Details
Cat No:T000133
Synonyms:4,9-Epoxycevane-3-beta,4-beta,14,15-alpha,16-beta,20-hexol 3-veratrate
Molecular Formula:C36H51NO10
Molecular Weight:657.79 g/mol
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Melting Point:259-261 °C
Purity:≥ 96 % (TLC, mass spectrometry)
Cat No:T000133
Cas No:31329-58-5
Product-Name:VERATROYLZYGADENINE

As an analog of Veratridine, it is a Na+ channel activator and a potent neurotoxic. Indeed, it is a depolarizing agent on membranes of nerve terminal, muscle and gland cells.


Steroid alkaloid, from plants of the Veratrum genus, Liliaceae

It has an effect on cardiac vessel system at the dosage of 1-50 μg/kg (i.v.)


- Kupchan. /Veratrum alkaloids. XXX. The structure and configuration of zygadenine./ J. Amer. Chem. Soc. (1959). 81:1925

- Fink et al., /Veratridine and other depolarizing agents counteract the inhibitory effect of Mg++ ion.../Nannyn-Schmiedeberg�s Arch. Pharmacol. (1990). 342N(1):53-60

- Tarvin et al., /Glucose induced electrical activity in the pancreatic beta-cells: effect of veratridine./ Amer. J. Physiol. (1981). 240:127-134

- Honerjager, /A neutrally mediated inotropic effect of veratridine and sevadine on isolated guinea pig papillary muscle./ Nannyn Schmiederberg/'s Arch. Pharmacol. (1980). 314:157-160



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