PEMPIDINE Tartrate

Melting Point:150-151°C
Appearance:colorless crystal powder
Purity:min. 98%.
TLC (Silufol UV-254, MeOH:NH3(25%) Rf 0.78, development with Dragendorff� reagent); NMR (D2O).

Cat No:	T000025
Cas No:	546-48-5
Product-Name:	PEMPIDINE Tartrate
Related Cas:	79-55-0 (base), 6152-93-8 (tosilate).
IUPAC Name:	(2R,3R)-2,3-dihydroxybutanedioic acid;1,2,2,6,6-pentamethylpiperidine
InChI:	InChI=1S/C10H21N.C4H6O6/c1-9(2)7-6-8-10(3,4)11(9)5;5-1(3(7)8)2(6)4(9)10/h6-8H2,1-5H3;1-2,5-6H,(H,7,8)(H,9,10)/t;1-,2-/m.1/s1
InChIKey:	AAFNEINEQRQMTF-LREBCSMRSA-N
SMILES:	CC1(CCCC(N1C)(C)C)C.C(C(C(=O)O)O)(C(=O)O)O

PEMPIDINE Tartrate(CAS 546-48-5) is a neuronal nicotinic AChR antagonist. Potent ganglioblocker. Antihypertensive. Good penetration of biological membranes. Monocyclic analog of TEMECHINE.

Piperidine derivative,, synthetic.

For comparative information see the attached tables. Cell permeant central nicotinic acetylcholine receptor blocker without action on skeleton muscle innervation.

Produces a slowly developing voltage-dependent block of ionoforetically activated cholinergic currents of the lobster gastric mill [3, 4].

CNS activity: see the attached table.

35 mg/kg increases ATP and decreases AMP [5]. Modulation of Dopamine release [6]. Increases IP level (Sherman).

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- Spinks et al., Brit.J.Pharm. (1958). 13(4):501-520