Melting Point:269-271 °C
Appearance:White crystal powder
Purity: 99% TLC [silufol, benzene:acetone (2:1)], mass spectrometry, melting point
| Cat No: | T000016 |
| Cas No: | 2446-62-0 (parent) |
| Product-Name: | DEOXYVACISINONE HCl |
DEOXYVACISINONE HCl inhibits cholinesterase activity in vitro.
In vivo, high doses induce sleep and enhance the effect of soporifics.
Quinazolone alkaloid, synthetic.
High dose inhibits orientation reaction and motor functions. So, it induces somnolence, even sleep.
Half and quarter LD<sub>50</sub> doses (= moderate doses) enhance the effect of soporifics. In vitro, it causes weak inhibition of cholinesterase acitivity with IC<sub>50</sub> = 6.2x10<sup>-4</sup> g/ml, and of monoaminoxidase at 10<sup>-4</sup> M reduces by 18.8 % its activity.
- Fitzgerald et al., /6, 7, 8, 9-tetrahydropyrido-quinazoline, a new class of alkaloids from Mackinlava species (Araliaceae)/ Aust. J. Chem. (1966). 19(1):151-159
- Spath et al., /Uber Derivate des Peganins und ihre Ring-Homologen/ J. Mitt. Uber Peganin, Chem. Ber. 6 (1935). 68:2221-2226
- Jen et al., /A new class of antihypertensive agents, 1, 2, 3, 5-Tetrahydroimidazo [2,1-b] quinazoline./ J. Med. Chem.1 (1972). 15(7):727-731
- Touliaganov, Ph. D. Thesis, Moscow (1981) (Russian).
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