(±)12-HETE


CAS No. : 71030-37-0

(±)12-HETE,71030-37-0
Product Details
Cat No:R067261
Synonyms:(±)12-hydroxy-5Z,8Z,10E,14Z-eicosatetraenoic acid
Molecular Formula:C20H32O3
Molecular Weight:320.473
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Cat No:R067261
Cas No:71030-37-0
Product-Name:(±)12-HETE
IUPAC Name:(5Z,8Z,10E,14Z)-12-hydroxyicosa-5,8,10,14-tetraenoic acid
InChI:InChI=1S/C20H32O3/c1-2-3-4-5-10-13-16-19(21)17-14-11-8-6-7-9-12-15-18-20(22)23/h7-11,13-14,17,19,21H,2-6,12,15-16,18H2,1H3,(H,22,23)/b9-7-,11-8-,13-10-,17-14+
InChIKey:ZNHVWPKMFKADKW-VXBMJZGYSA-N
SMILES:CCCCCC=CCC(C=CC=CCC=CCCCC(=O)O)O
(±)12-HETE is one of the six monohydroxy fatty acids produced by the non-enzymatic oxidation of arachidonic acid. The biological activity of (±)12-HETE is similar to that of its constituent enantiomers (Item Nos. 34560 and 34570). It aggregates neutrophils with an EC50 value of 40 nM.
1.O/'Flaherty, J.T.,Thomas, M.J.,Lees, C.J., et al. Neutrophil-aggregating activity of monohydroxyeicosatetraenoic acids. American Journal of Pathology 104, 55-62 (1981).
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