CAS No. : 83952-40-3

Product Details
Cat No:R067222
Synonyms:(±)-5-hydroxy-6E,8Z,11Z,14Z,17Z-eicosapentaenoic acid
Molecular Formula:C20H30O3
Molecular Weight:318.457
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Cat No:R067222
Cas No:83952-40-3
IUPAC Name:(6E,8Z,11Z,14Z,17Z)-5-hydroxyicosa-6,8,11,14,17-pentaenoic acid
(±)5-HEPE is produced by non-enzymatic oxidation of EPA. It contains equal amounts of 5(S)-HEPE and 5(R)-HEPE. The biological activity of (±)5-HEPE is likely mediated by one of the individual isomers, most commonly the 5(S) isomer in mammalian systems. EPA can be metabolized to 5-HEPE in human and bovine neutrophils, and human eosinophils, which is further metabolized to 5-oxoEPE and LTB5. The 5-series metabolites of EPA, namely 5-HEPE, 5-oxoEPE, and LTB5, have significantly decreased biological effects compared to the arachidonic acid-derived metabolites.
1.Powell, W.S.,Gravel, S. and Gravelle, F. Formation of a 5-oxo metabolite of 5,8,11,14,17-eicosapentaenoic acid and its effects on human neutrophils and eosinophils. Journal of Lipid Research 36, 2590-2598 (1995).
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