(±)9(10)-EpOME


CAS No. :

(±)9(10)-EpOME,
Product Details
Cat No:R067143
Synonyms:(±)9,10-EODE;Leukotoxin
Molecular Formula:C18H32O3
Molecular Weight:296.5
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Cat No:R067143
Product-Name:(±)9(10)-EpOME
InChI:InChI=1S/C18H32O3/c1-2-3-4-5-7-10-13-16-17(21-16)14-11-8-6-9-12-15-18(19)20/h7,10,16-17H,2-6,8-9,11-15H2,1H3,(H,19,20)/b10-7-/t16-,17+/m1/s1/i7D,10D,16D,17D
InChIKey:FBUKMFOXMZRGRB-XKJZPFPASA-N
SMILES:CCCCC/C=CC[C@@H](O1)[C@@H]1CCCCCCCC(O)=O
(±)9(10)-EpOME is the 9,10-cis epoxide of linoleic acid, generated by neutrophils during the oxidative burst. It has been recovered from the lungs of hyperoxic rats and from humans with acute respiratory distress syndrome. Mitochondrial dysfunction is the main feature of (±)9(10)-EpOME cytotoxicity, which may be due to the diol metabolites as well as the parent epoxide.
1.Hayakawa, M.,Sugiyama, S.,Takamura, T., et al. Neutrophils biosynthesize leukotoxin, 9,10-epoxy-12-octadecenoate. Biochemical and Biophysical Research Communications 137, 424-430 (1986).
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