(±)14(15)-DiHET


CAS No. :

(±)14(15)-DiHET,
Product Details
Cat No:R067142
Synonyms:(±)14,15-DiHETrE
Molecular Formula:C20H34O4
Molecular Weight:338.5
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Cat No:R067142
Product-Name:(±)14(15)-DiHET
InChI:InChI=1S/C20H34O4/c1-2-3-12-15-18(21)19(22)16-13-10-8-6-4-5-7-9-11-14-17-20(23)24/h4,6-7,9-10,13,18-19,21-22H,2-3,5,8,11-12,14-17H2,1H3,(H,23,24)/b6-4-,9-7-,13-10-/t18-,19+/m1/s1
InChIKey:SYAWGTIVOGUZMM-KZTFMOQPSA-N
SMILES:CCCCC[C@@H](O)[C@@H](O)C/C=CC/C=CC/C=CCCCC(O)=O
Epoxide hydrolases convert the EETs into vicinal diols, with the concurrent loss of much of their biological activity. (±)14(15)-DiHET is the urinary metabolite of (±)14(15)-EET (Item No. 50651) which has been documented by GC-MS to be elevated in pregnancy-induced hypertension.
1.Oliw, E.H.,Guengerich, F.P., and Oates, J.A. Oxygenation of arachidonic acid by hepatic monooxygenases. Isolation and metabolism of four epoxide intermediates. The Journal of Biological Chemisty 257, 3771-3781 (1982).
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