(±)11(12)-DiHET


CAS No. :

(±)11(12)-DiHET,
Product Details
Cat No:R067141
Synonyms:(±)11,12-DiHETrE
Molecular Formula:C20H34O4
Molecular Weight:338.5
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Cat No:R067141
Product-Name:(±)11(12)-DiHET
InChI:InChI=1S/C20H34O4/c1-2-3-4-5-9-12-15-18(21)19(22)16-13-10-7-6-8-11-14-17-20(23)24/h6,8-10,12-13,18-19,21-22H,2-5,7,11,14-17H2,1H3,(H,23,24)/b8-6-,12-9-,13-10-/t18-,19+/m1/s1
InChIKey:LRPPQRCHCPFBPE-LZXKBWHHSA-N
SMILES:CCCCC/C=CC[C@@H](O)[C@@H](O)C/C=CC/C=CCCCC(O)=O
Epoxide hydrolases convert the EETs into vicinal diols, with the concurrent loss of much of their biological activity. (±)11(12)-DiHET relaxes U-46619 (Item No. 16450)-contracted artery rings with approximately 70% of the magnitude of (±)11(12)-EET (Item No. 50511).
1.Oliw, E.H.,Guengerich, F.P., and Oates, J.A. Oxygenation of arachidonic acid by hepatic monooxygenases. Isolation and metabolism of four epoxide intermediates. The Journal of Biological Chemisty 257, 3771-3781 (1982).
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