(R)-IMPP


CAS No. :

(R)-IMPP,
Product Details
Cat No:R066864
Synonyms:(R)-N-(isoquinolin-1-yl)-3-(4-methoxyphenyl)-N-(piperidin-3-yl)propanamide
Molecular Formula:C24H27N3O2
Molecular Weight:389.5
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Cat No:R066864
Product-Name:(R)-IMPP
InChI:InChI=1S/C24H27N3O2/c1-29-21-11-8-18(9-12-21)10-13-23(28)27(20-6-4-15-25-17-20)24-22-7-3-2-5-19(22)14-16-26-24/h2-3,5,7-9,11-12,14,16,20,25H,4,6,10,13,15,17H2,1H3/t20-/m1/s1
InChIKey:OKTGXQMSOIQCTJ-HXUWFJFHSA-N
SMILES:COC1=CC=C(CCC(N(C2=C(C=CC=C3)C3=CC=N2)[C@H]4CNCCC4)=O)C=C1
(R)-IMPP is a cell-permeable inhibitor of the secretion of proprotein convertase subtilisin/kexin type 9 (PCSK9; IC50 = 4.8 µM). It promotes the uptake of LDL cholesterol in hepatoma cells by increasing LDL receptor levels. (R)-IMPP apparently impairs PCSK9 secretion by causing transcript-dependent inhibition of PCSK9 translation.
1.Petersen, D.N.,Hawkins, J.,Ruangsiriluk, W., et al. A small-molecule anti-secretagogue of PCSK9 targets the 80S ribosome to inhibit PCSK9 protein translation. Cell. Chem. Biol. 23, 1-10 (2016).
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